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(18)F-Based Pretargeted PET Imaging Based on Bioorthogonal Diels–Alder Click Chemistry

[Image: see text] A first-of-its-kind (18)F pretargeted PET imaging approach based on the bioorthogonal inverse electron demand Diels–Alder (IEDDA) reaction between tetrazine (Tz) and trans-cyclooctene (TCO) is presented. As proof-of-principle, a TCO-bearing immunoconjugate of the anti-CA19.9 antibo...

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Detalles Bibliográficos
Autores principales:	Meyer, Jan-Philip, Houghton, Jacob L., Kozlowski, Paul, Abdel-Atti, Dalya, Reiner, Thomas, Pillarsetty, Naga Vara Kishore, Scholz, Wolfgang W., Zeglis, Brian M., Lewis, Jason S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759614/ https://www.ncbi.nlm.nih.gov/pubmed/26479967 http://dx.doi.org/10.1021/acs.bioconjchem.5b00504

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