The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke

The clinical relevance of the transient intraluminal filament model of middle cerebral artery occlusion (tMCAO) has been questioned due to distinct cerebral blood flow profiles upon reperfusion between tMCAO (abrupt reperfusion) and alteplase treatment (gradual reperfusion), resulting in differing p...

Descripción completa

Detalles Bibliográficos
Autores principales: Sutherland, Brad A, Neuhaus, Ain A, Couch, Yvonne, Balami, Joyce S, DeLuca, Gabriele C, Hadley, Gina, Harris, Scarlett L, Grey, Adam N, Buchan, Alastair M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2015
Materias:
Brief Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759672/
https://www.ncbi.nlm.nih.gov/pubmed/26661175
http://dx.doi.org/10.1177/0271678X15606722
_version_ 1782416764866396160
author Sutherland, Brad A
Neuhaus, Ain A
Couch, Yvonne
Balami, Joyce S
DeLuca, Gabriele C
Hadley, Gina
Harris, Scarlett L
Grey, Adam N
Buchan, Alastair M
author_facet Sutherland, Brad A
Neuhaus, Ain A
Couch, Yvonne
Balami, Joyce S
DeLuca, Gabriele C
Hadley, Gina
Harris, Scarlett L
Grey, Adam N
Buchan, Alastair M
author_sort Sutherland, Brad A
collection PubMed
description The clinical relevance of the transient intraluminal filament model of middle cerebral artery occlusion (tMCAO) has been questioned due to distinct cerebral blood flow profiles upon reperfusion between tMCAO (abrupt reperfusion) and alteplase treatment (gradual reperfusion), resulting in differing pathophysiologies. Positive results from recent endovascular thrombectomy trials, where the occluding clot is mechanically removed, could revolutionize stroke treatment. The rapid cerebral blood flow restoration in both tMCAO and endovascular thrombectomy provides clinical relevance for this pre-clinical model. Any future clinical trials of neuroprotective agents as adjuncts to endovascular thrombectomy should consider tMCAO as the model of choice to determine pre-clinical efficacy.
format Online
Article
Text
id pubmed-4759672
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-47596722016-03-10 The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke Sutherland, Brad A Neuhaus, Ain A Couch, Yvonne Balami, Joyce S DeLuca, Gabriele C Hadley, Gina Harris, Scarlett L Grey, Adam N Buchan, Alastair M J Cereb Blood Flow Metab Brief Opinion The clinical relevance of the transient intraluminal filament model of middle cerebral artery occlusion (tMCAO) has been questioned due to distinct cerebral blood flow profiles upon reperfusion between tMCAO (abrupt reperfusion) and alteplase treatment (gradual reperfusion), resulting in differing pathophysiologies. Positive results from recent endovascular thrombectomy trials, where the occluding clot is mechanically removed, could revolutionize stroke treatment. The rapid cerebral blood flow restoration in both tMCAO and endovascular thrombectomy provides clinical relevance for this pre-clinical model. Any future clinical trials of neuroprotective agents as adjuncts to endovascular thrombectomy should consider tMCAO as the model of choice to determine pre-clinical efficacy. SAGE Publications 2015-10-02 2016-02 /pmc/articles/PMC4759672/ /pubmed/26661175 http://dx.doi.org/10.1177/0271678X15606722 Text en © The Author(s) 2015 http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Brief Opinion
Sutherland, Brad A
Neuhaus, Ain A
Couch, Yvonne
Balami, Joyce S
DeLuca, Gabriele C
Hadley, Gina
Harris, Scarlett L
Grey, Adam N
Buchan, Alastair M
The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke
title The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke
title_full The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke
title_fullStr The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke
title_full_unstemmed The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke
title_short The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke
title_sort transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke
topic Brief Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759672/
https://www.ncbi.nlm.nih.gov/pubmed/26661175
http://dx.doi.org/10.1177/0271678X15606722
work_keys_str_mv AT sutherlandbrada thetransientintraluminalfilamentmiddlecerebralarteryocclusionmodelasamodelofendovascularthrombectomyinstroke
AT neuhausaina thetransientintraluminalfilamentmiddlecerebralarteryocclusionmodelasamodelofendovascularthrombectomyinstroke
AT couchyvonne thetransientintraluminalfilamentmiddlecerebralarteryocclusionmodelasamodelofendovascularthrombectomyinstroke
AT balamijoyces thetransientintraluminalfilamentmiddlecerebralarteryocclusionmodelasamodelofendovascularthrombectomyinstroke
AT delucagabrielec thetransientintraluminalfilamentmiddlecerebralarteryocclusionmodelasamodelofendovascularthrombectomyinstroke
AT hadleygina thetransientintraluminalfilamentmiddlecerebralarteryocclusionmodelasamodelofendovascularthrombectomyinstroke
AT harrisscarlettl thetransientintraluminalfilamentmiddlecerebralarteryocclusionmodelasamodelofendovascularthrombectomyinstroke
AT greyadamn thetransientintraluminalfilamentmiddlecerebralarteryocclusionmodelasamodelofendovascularthrombectomyinstroke
AT buchanalastairm thetransientintraluminalfilamentmiddlecerebralarteryocclusionmodelasamodelofendovascularthrombectomyinstroke
AT sutherlandbrada transientintraluminalfilamentmiddlecerebralarteryocclusionmodelasamodelofendovascularthrombectomyinstroke
AT neuhausaina transientintraluminalfilamentmiddlecerebralarteryocclusionmodelasamodelofendovascularthrombectomyinstroke
AT couchyvonne transientintraluminalfilamentmiddlecerebralarteryocclusionmodelasamodelofendovascularthrombectomyinstroke
AT balamijoyces transientintraluminalfilamentmiddlecerebralarteryocclusionmodelasamodelofendovascularthrombectomyinstroke
AT delucagabrielec transientintraluminalfilamentmiddlecerebralarteryocclusionmodelasamodelofendovascularthrombectomyinstroke
AT hadleygina transientintraluminalfilamentmiddlecerebralarteryocclusionmodelasamodelofendovascularthrombectomyinstroke
AT harrisscarlettl transientintraluminalfilamentmiddlecerebralarteryocclusionmodelasamodelofendovascularthrombectomyinstroke
AT greyadamn transientintraluminalfilamentmiddlecerebralarteryocclusionmodelasamodelofendovascularthrombectomyinstroke
AT buchanalastairm transientintraluminalfilamentmiddlecerebralarteryocclusionmodelasamodelofendovascularthrombectomyinstroke

Ejemplares similares