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Incidence of Endophthalmitis after Intravitreal Bevacizumab using Aliquots Prepared On-site in 2 Operating Rooms in Kuwait

PURPOSE: To report the incidence of endophthalmitis after intravitreal injection of bevacizumab and the outcomes of treatment of endophthalmitis at two centers in Kuwait. SUBJECTS AND METHODS: The aliquots of bevacizumab were prepared under aseptic precautions and administered in the operating theat...

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Autores principales: Wani, Vivek B., Al-Kandari, Jamal, Sabti, Khalid, Aljassar, Faisal, Qali, Hussain, Kumar, Niranjan, Uboweja, Anilkumar, Al-Sabah, Khalid, Diab, Fahad A., Al-Rashidi, Saleh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759906/
https://www.ncbi.nlm.nih.gov/pubmed/26957841
http://dx.doi.org/10.4103/0974-9233.171784
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author Wani, Vivek B.
Al-Kandari, Jamal
Sabti, Khalid
Aljassar, Faisal
Qali, Hussain
Kumar, Niranjan
Uboweja, Anilkumar
Al-Sabah, Khalid
Diab, Fahad A.
Al-Rashidi, Saleh
author_facet Wani, Vivek B.
Al-Kandari, Jamal
Sabti, Khalid
Aljassar, Faisal
Qali, Hussain
Kumar, Niranjan
Uboweja, Anilkumar
Al-Sabah, Khalid
Diab, Fahad A.
Al-Rashidi, Saleh
author_sort Wani, Vivek B.
collection PubMed
description PURPOSE: To report the incidence of endophthalmitis after intravitreal injection of bevacizumab and the outcomes of treatment of endophthalmitis at two centers in Kuwait. SUBJECTS AND METHODS: The aliquots of bevacizumab were prepared under aseptic precautions and administered in the operating theater on the same day at both centers. All patients received antibiotic drops after injection of bevacizumab. Data were collected on the number of cases that received intravitreal bevacizumab (IVB) and those that developed endophthalmitis were identified at the two centers. All cases of endophthalmitis received an intravitreal antibiotic injection and additional treatments as warranted. Data were collected on the outcomes of endophthalmitis treatment. RESULTS: There were 5 cases of endophthalmitis among a total of 5429 injections (0.09%: Confidence interval: 0.084–0.1). The incidence was 3 cases among 4690 (0.06%) and 2 cases among 739 injections (0.027%) at each center, respectively (P = 0.08). Four cases of endophthalmitis were culture-positive and organisms isolated were, coagulase negative Staphylococcus in 2 cases, Staphylococcus lugdunensis and Streptococcus pneumoniae in 1 case each. The final visual acuity was better than pre-IVB in 3 cases, same as pre-IVB in 1 case and worse in 1 case with streptococcal infection. No eyes developed phthisis bulbi or required enucleation. CONCLUSIONS: The incidence of endophthalmitis after intravitreal injection of bevacizumab using aliquots prepared in the operating room is comparable to other studies. There were no clusters of endophthalmitis cases.
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spelling pubmed-47599062016-03-08 Incidence of Endophthalmitis after Intravitreal Bevacizumab using Aliquots Prepared On-site in 2 Operating Rooms in Kuwait Wani, Vivek B. Al-Kandari, Jamal Sabti, Khalid Aljassar, Faisal Qali, Hussain Kumar, Niranjan Uboweja, Anilkumar Al-Sabah, Khalid Diab, Fahad A. Al-Rashidi, Saleh Middle East Afr J Ophthalmol Original Article PURPOSE: To report the incidence of endophthalmitis after intravitreal injection of bevacizumab and the outcomes of treatment of endophthalmitis at two centers in Kuwait. SUBJECTS AND METHODS: The aliquots of bevacizumab were prepared under aseptic precautions and administered in the operating theater on the same day at both centers. All patients received antibiotic drops after injection of bevacizumab. Data were collected on the number of cases that received intravitreal bevacizumab (IVB) and those that developed endophthalmitis were identified at the two centers. All cases of endophthalmitis received an intravitreal antibiotic injection and additional treatments as warranted. Data were collected on the outcomes of endophthalmitis treatment. RESULTS: There were 5 cases of endophthalmitis among a total of 5429 injections (0.09%: Confidence interval: 0.084–0.1). The incidence was 3 cases among 4690 (0.06%) and 2 cases among 739 injections (0.027%) at each center, respectively (P = 0.08). Four cases of endophthalmitis were culture-positive and organisms isolated were, coagulase negative Staphylococcus in 2 cases, Staphylococcus lugdunensis and Streptococcus pneumoniae in 1 case each. The final visual acuity was better than pre-IVB in 3 cases, same as pre-IVB in 1 case and worse in 1 case with streptococcal infection. No eyes developed phthisis bulbi or required enucleation. CONCLUSIONS: The incidence of endophthalmitis after intravitreal injection of bevacizumab using aliquots prepared in the operating room is comparable to other studies. There were no clusters of endophthalmitis cases. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4759906/ /pubmed/26957841 http://dx.doi.org/10.4103/0974-9233.171784 Text en Copyright: © Middle East African Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Wani, Vivek B.
Al-Kandari, Jamal
Sabti, Khalid
Aljassar, Faisal
Qali, Hussain
Kumar, Niranjan
Uboweja, Anilkumar
Al-Sabah, Khalid
Diab, Fahad A.
Al-Rashidi, Saleh
Incidence of Endophthalmitis after Intravitreal Bevacizumab using Aliquots Prepared On-site in 2 Operating Rooms in Kuwait
title Incidence of Endophthalmitis after Intravitreal Bevacizumab using Aliquots Prepared On-site in 2 Operating Rooms in Kuwait
title_full Incidence of Endophthalmitis after Intravitreal Bevacizumab using Aliquots Prepared On-site in 2 Operating Rooms in Kuwait
title_fullStr Incidence of Endophthalmitis after Intravitreal Bevacizumab using Aliquots Prepared On-site in 2 Operating Rooms in Kuwait
title_full_unstemmed Incidence of Endophthalmitis after Intravitreal Bevacizumab using Aliquots Prepared On-site in 2 Operating Rooms in Kuwait
title_short Incidence of Endophthalmitis after Intravitreal Bevacizumab using Aliquots Prepared On-site in 2 Operating Rooms in Kuwait
title_sort incidence of endophthalmitis after intravitreal bevacizumab using aliquots prepared on-site in 2 operating rooms in kuwait
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759906/
https://www.ncbi.nlm.nih.gov/pubmed/26957841
http://dx.doi.org/10.4103/0974-9233.171784
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