Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses

Despite the importance of the co-receptor PD-1 in T cell immunity, the upstream signaling pathway that regulates PD-1 expression has not been defined. Glycogen synthase kinase 3 (GSK-3, isoforms α and β) is a serine-threonine kinase implicated in cellular processes. Here, we identified GSK-3 as a ke...

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Detalles Bibliográficos
Autores principales: Taylor, Alison, Harker, James A., Chanthong, Kittiphat, Stevenson, Philip G., Zuniga, Elina I., Rudd, Christopher E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760122/
https://www.ncbi.nlm.nih.gov/pubmed/26885856
http://dx.doi.org/10.1016/j.immuni.2016.01.018

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