PD-1 expression conditions T cell avidity within an antigen-specific repertoire

Despite its negative regulatory role on tumor-specific T cells, Programmed cell death 1 (PD-1) is also a marker of activated tumor-infiltrating T cells. In cancer, PD-1 blockade partially reverses T cell dysfunction allowing the amplification of tumor reactive T cells. Here, we investigated the role...

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Detalles Bibliográficos
Autores principales: Simon, Sylvain, Vignard, Virginie, Florenceau, Laetitia, Dreno, B., Khammari, A., Lang, F., Labarriere, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760290/
https://www.ncbi.nlm.nih.gov/pubmed/26942093
http://dx.doi.org/10.1080/2162402X.2015.1104448

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