Activation of cytomegalovirus-specific CD8(+) T-cell response by antibody-mediated peptide-major histocompatibility class I complexes

Imposing antigenicity on tumor cells is a key step toward successful cancer-immunotherapy. A cytomegalovirus-derived peptide recombinantly fused to a major histocompatibility class I complex and a monoclonal antibody can be targeted to tumor cells by antibody-mediated delivery and activate a strong...

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Detalles Bibliográficos
Autores principales: Schmittnaegel, Martina, Klein, Christian, Levitsky, Victor, Knoetgen, Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760341/
https://www.ncbi.nlm.nih.gov/pubmed/26942061
http://dx.doi.org/10.1080/2162402X.2015.1052930
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author Schmittnaegel, Martina
Klein, Christian
Levitsky, Victor
Knoetgen, Hendrik
author_facet Schmittnaegel, Martina
Klein, Christian
Levitsky, Victor
Knoetgen, Hendrik
author_sort Schmittnaegel, Martina
collection PubMed
description Imposing antigenicity on tumor cells is a key step toward successful cancer-immunotherapy. A cytomegalovirus-derived peptide recombinantly fused to a major histocompatibility class I complex and a monoclonal antibody can be targeted to tumor cells by antibody-mediated delivery and activate a strong and specific CD8(+) T cell response.
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spelling pubmed-47603412016-03-03 Activation of cytomegalovirus-specific CD8(+) T-cell response by antibody-mediated peptide-major histocompatibility class I complexes Schmittnaegel, Martina Klein, Christian Levitsky, Victor Knoetgen, Hendrik Oncoimmunology Author's View Imposing antigenicity on tumor cells is a key step toward successful cancer-immunotherapy. A cytomegalovirus-derived peptide recombinantly fused to a major histocompatibility class I complex and a monoclonal antibody can be targeted to tumor cells by antibody-mediated delivery and activate a strong and specific CD8(+) T cell response. Taylor & Francis 2015-05-29 /pmc/articles/PMC4760341/ /pubmed/26942061 http://dx.doi.org/10.1080/2162402X.2015.1052930 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Schmittnaegel, Martina
Klein, Christian
Levitsky, Victor
Knoetgen, Hendrik
Activation of cytomegalovirus-specific CD8(+) T-cell response by antibody-mediated peptide-major histocompatibility class I complexes
title Activation of cytomegalovirus-specific CD8(+) T-cell response by antibody-mediated peptide-major histocompatibility class I complexes
title_full Activation of cytomegalovirus-specific CD8(+) T-cell response by antibody-mediated peptide-major histocompatibility class I complexes
title_fullStr Activation of cytomegalovirus-specific CD8(+) T-cell response by antibody-mediated peptide-major histocompatibility class I complexes
title_full_unstemmed Activation of cytomegalovirus-specific CD8(+) T-cell response by antibody-mediated peptide-major histocompatibility class I complexes
title_short Activation of cytomegalovirus-specific CD8(+) T-cell response by antibody-mediated peptide-major histocompatibility class I complexes
title_sort activation of cytomegalovirus-specific cd8(+) t-cell response by antibody-mediated peptide-major histocompatibility class i complexes
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760341/
https://www.ncbi.nlm.nih.gov/pubmed/26942061
http://dx.doi.org/10.1080/2162402X.2015.1052930
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