Overexpression of Swedish mutant APP in aged astrocytes attenuates excitatory synaptic transmission

Amyloid precursor protein (APP), a type I transmembrane protein, has different aspects, namely, performs essential physiological functions and produces β‐amyloid peptide (Aβ). Overexpression of neuronal APP is responsible for synaptic dysfunction. In the central nervous system, astrocytes – a major...

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Detalles Bibliográficos
Autores principales: Katsurabayashi, Shutaro, Kawano, Hiroyuki, Ii, Miyuki, Nakano, Sachiko, Tatsumi, Chihiro, Kubota, Kaori, Takasaki, Kotaro, Mishima, Kenichi, Fujiwara, Michihiro, Iwasaki, Katsunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760399/
https://www.ncbi.nlm.nih.gov/pubmed/26733247
http://dx.doi.org/10.14814/phy2.12665

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