Cargando…

Novel hepatic microRNAs upregulated in human nonalcoholic fatty liver disease

MicroRNAs (miRNAs) control gene expression by reducing mRNA stability and translation. We aimed to identify alterations in human liver miRNA expression/function in nonalcoholic fatty liver disease (NAFLD). Subjects with the highest (median liver fat 30%, n = 15) and lowest (0%, n = 15) liver fat con...

Descripción completa

Detalles Bibliográficos
Autores principales:	Soronen, Jarkko, Yki‐Järvinen, Hannele, Zhou, You, Sädevirta, Sanja, Sarin, Antti‐Pekka, Leivonen, Marja, Sevastianova, Ksenia, Perttilä, Julia, Laurila, Pirkka‐Pekka, Sigruener, Alexander, Schmitz, Gerd, Olkkonen, Vesa M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760405/ https://www.ncbi.nlm.nih.gov/pubmed/26733244 http://dx.doi.org/10.14814/phy2.12661

Ejemplares similares

Adipose tissue gene expression analysis reveals changes in inflammatory, mitochondrial respiratory and lipid metabolic pathways in obese insulin-resistant subjects
por: Soronen, Jarkko, et al.
Publicado: (2012)

USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages
por: Ruuth, Maija, et al.
Publicado: (2018)

OSBP-Related Proteins (ORPs) in Human Adipose Depots and Cultured Adipocytes: Evidence for Impacts on the Adipocyte Phenotype
por: Zhou, You, et al.
Publicado: (2012)

Comparison of Dorsocervical With Abdominal Subcutaneous Adipose Tissue in Patients With and Without Antiretroviral Therapy–Associated Lipodystrophy
por: Sevastianova, Ksenia, et al.
Publicado: (2011)

Silencing of ANGPTL 3 (angiopoietin-like protein 3) in human hepatocytes results in decreased expression of gluconeogenic genes and reduced triacylglycerol-rich VLDL secretion upon insulin stimulation
por: Tikka, Anna, et al.
Publicado: (2014)

Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) – an 11-Year Prospective Study
por: Lallukka, Susanna, et al.
Publicado: (2017)

Continuous Grading of Early Fibrosis in NAFLD Using Label-Free Imaging: A Proof-of-Concept Study
por: Pirhonen, Juho, et al.
Publicado: (2016)

Phosphorylated IGFBP-1 as a non-invasive predictor of liver fat in NAFLD
por: Petäjä, Elina M., et al.
Publicado: (2016)

Overfeeding Saturated Fat Increases LDL (Low-Density Lipoprotein) Aggregation Susceptibility While Overfeeding Unsaturated Fat Decreases Proteoglycan-Binding of Lipoproteins
por: Ruuth, Maija, et al.
Publicado: (2021)

Hematopoietic upstream stimulating factor 1 deficiency is associated with increased atherosclerosis susceptibility in LDL receptor knockout mice
por: Hoekstra, Menno, et al.
Publicado: (2021)

Metabolomes of mitochondrial diseases and inclusion body myositis patients: treatment targets and biomarkers
por: Buzkova, Jana, et al.
Publicado: (2018)

Nutritional Modulation of Non-Alcoholic Fatty Liver Disease and Insulin Resistance
por: Yki-Järvinen, Hannele
Publicado: (2015)

Osbpl8 Deficiency in Mouse Causes an Elevation of High-Density Lipoproteins and Gender-Specific Alterations of Lipid Metabolism
por: Béaslas, Olivier, et al.
Publicado: (2013)

Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease
por: Luukkonen, Panu K., et al.
Publicado: (2020)

Is There Evidence to Support Use of Premixed or Prandial Insulin Regimens in Insulin-Naive or Previously Insulin-Treated Type 2 Diabetic Patients?
por: Yki-Järvinen, Hannele, et al.
Publicado: (2013)

The quest for the missing links in fatty liver genetics: Deep learning to the rescue!
por: Qadri, Sami, et al.
Publicado: (2022)

Definitions of Normal Liver Fat and the Association of Insulin Sensitivity with Acquired and Genetic NAFLD—A Systematic Review
por: Petäjä, Elina M., et al.
Publicado: (2016)

Hepatic Stearoyl-CoA Desaturase (SCD)-1 Activity and Diacylglycerol but Not Ceramide Concentrations Are Increased in the Nonalcoholic Human Fatty Liver
por: Kotronen, Anna, et al.
Publicado: (2009)

The Contribution of GWAS Loci in Familial Dyslipidemias
por: Ripatti, Pietari, et al.
Publicado: (2016)

OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism
por: Perttilä, Julia, et al.
Publicado: (2009)

Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes
por: Ahonen, Maria A., et al.
Publicado: (2022)

Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars
por: Luukkonen, Panu K., et al.
Publicado: (2018)

Quantitative PCR provides a simple and accessible method for quantitative microbiota profiling
por: Jian, Ching, et al.
Publicado: (2020)

In vitro Effects of Bacterial Exposure on Secretion of Zonulin Family Peptides and Their Detection in Human Tissue Samples
por: Jian, Ching, et al.
Publicado: (2022)

OSBP-Related Protein 8 (ORP8) Regulates Plasma and Liver Tissue Lipid Levels and Interacts with the Nucleoporin Nup62
por: Zhou, Tianhong, et al.
Publicado: (2011)

Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids
por: Orešič, Matej, et al.
Publicado: (2013)

Global Transcript Profiles of Fat in Monozygotic Twins Discordant for BMI: Pathways behind Acquired Obesity
por: Pietiläinen, Kirsi H, et al.
Publicado: (2008)

Black Mesoporous Silicon as a Contrast Agent for LED-Based 3D Photoacoustic Tomography
por: Xu, Wujun, et al.
Publicado: (2020)

Assembly of ﬂuorophore J-aggregates with nanospacer onto mesoporous nanoparticles for enhanced photoacoustic imaging
por: Xu, Wujun, et al.
Publicado: (2023)

Obesity Modifies the Performance of Fibrosis Biomarkers in Nonalcoholic Fatty Liver Disease
por: Qadri, Sami, et al.
Publicado: (2021)

OSBP-Related Protein Family in Lipid Transport Over Membrane Contact Sites
por: Olkkonen, Vesa M.
Publicado: (2015)

OSBP-Related Proteins: Liganding by Glycerophospholipids Opens New Insight into Their Function
por: Olkkonen, Vesa M.
Publicado: (2013)

Effects of Exenatide on Measures of β-Cell Function After 3 Years in Metformin-Treated Patients With Type 2 Diabetes
por: Bunck, Mathijs C., et al.
Publicado: (2011)

Exenatide Affects Circulating Cardiovascular Risk Biomarkers Independently of Changes in Body Composition
por: Bunck, Mathijs C., et al.
Publicado: (2010)

Better glycaemic control and less hypoglycaemia with insulin glargine 300 U/mL vs glargine 100 U/mL: 1‐year patient‐level meta‐analysis of the EDITION clinical studies in people with type 2 diabetes
por: Ritzel, Robert, et al.
Publicado: (2017)

Increased Visceral Adipose Tissue as a Potential Risk Factor in Patients with Embolic Stroke of Undetermined Source (ESUS)
por: Muuronen, Antti T., et al.
Publicado: (2015)

Insulin like growth factor-I in acute subarachnoid hemorrhage: a prospective cohort study
por: Bendel, Stepani, et al.
Publicado: (2010)

In Vitro Dissolution Methods for Hydrophilic and Hydrophobic Porous Silicon Microparticles
por: Mönkäre, Juha, et al.
Publicado: (2011)

Pathogenesis of Age-Related Osteoporosis: Impaired Mechano-Responsiveness of Bone Is Not the Culprit
por: Leppänen, Olli V., et al.
Publicado: (2008)

Correction: Pathogenesis of Age-Related Osteoporosis: Impaired Mechano-Responsiveness of Bone Is Not the Culprit
por: Leppänen, Olli V., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_353j0msns1ooui1eepcsohk9uv