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Efficacy of Favipiravir Alone and in Combination With Ribavirin in a Lethal, Immunocompetent Mouse Model of Lassa Fever
We studied the therapeutic potential of favipiravir (T-705) for Lassa fever, both alone and in combination with ribavirin. Favipiravir suppressed Lassa virus replication in cell culture by 5 log(10) units. In a novel lethal mouse model, it lowered the viremia level and the virus load in organs and n...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760419/ https://www.ncbi.nlm.nih.gov/pubmed/26531247 http://dx.doi.org/10.1093/infdis/jiv522 |
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author | Oestereich, Lisa Rieger, Toni Lüdtke, Anja Ruibal, Paula Wurr, Stephanie Pallasch, Elisa Bockholt, Sabrina Krasemann, Susanne Muñoz-Fontela, César Günther, Stephan |
author_facet | Oestereich, Lisa Rieger, Toni Lüdtke, Anja Ruibal, Paula Wurr, Stephanie Pallasch, Elisa Bockholt, Sabrina Krasemann, Susanne Muñoz-Fontela, César Günther, Stephan |
author_sort | Oestereich, Lisa |
collection | PubMed |
description | We studied the therapeutic potential of favipiravir (T-705) for Lassa fever, both alone and in combination with ribavirin. Favipiravir suppressed Lassa virus replication in cell culture by 5 log(10) units. In a novel lethal mouse model, it lowered the viremia level and the virus load in organs and normalized levels of cell-damage markers. Treatment with 300 mg/kg per day, commenced 4 days after infection, when the viremia level had reached 4 log(10) virus particles/mL, rescued 100% of Lassa virus–infected mice. We found a synergistic interaction between favipiravir and ribavirin in vitro and an increased survival rate and extended survival time when combining suboptimal doses in vivo. |
format | Online Article Text |
id | pubmed-4760419 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-47604192016-02-22 Efficacy of Favipiravir Alone and in Combination With Ribavirin in a Lethal, Immunocompetent Mouse Model of Lassa Fever Oestereich, Lisa Rieger, Toni Lüdtke, Anja Ruibal, Paula Wurr, Stephanie Pallasch, Elisa Bockholt, Sabrina Krasemann, Susanne Muñoz-Fontela, César Günther, Stephan J Infect Dis Major Articles and Brief Reports We studied the therapeutic potential of favipiravir (T-705) for Lassa fever, both alone and in combination with ribavirin. Favipiravir suppressed Lassa virus replication in cell culture by 5 log(10) units. In a novel lethal mouse model, it lowered the viremia level and the virus load in organs and normalized levels of cell-damage markers. Treatment with 300 mg/kg per day, commenced 4 days after infection, when the viremia level had reached 4 log(10) virus particles/mL, rescued 100% of Lassa virus–infected mice. We found a synergistic interaction between favipiravir and ribavirin in vitro and an increased survival rate and extended survival time when combining suboptimal doses in vivo. Oxford University Press 2016-03-15 2015-11-03 /pmc/articles/PMC4760419/ /pubmed/26531247 http://dx.doi.org/10.1093/infdis/jiv522 Text en © The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, contact journals.permissions@oup.com. |
spellingShingle | Major Articles and Brief Reports Oestereich, Lisa Rieger, Toni Lüdtke, Anja Ruibal, Paula Wurr, Stephanie Pallasch, Elisa Bockholt, Sabrina Krasemann, Susanne Muñoz-Fontela, César Günther, Stephan Efficacy of Favipiravir Alone and in Combination With Ribavirin in a Lethal, Immunocompetent Mouse Model of Lassa Fever |
title | Efficacy of Favipiravir Alone and in Combination With Ribavirin in a Lethal, Immunocompetent Mouse Model of Lassa Fever |
title_full | Efficacy of Favipiravir Alone and in Combination With Ribavirin in a Lethal, Immunocompetent Mouse Model of Lassa Fever |
title_fullStr | Efficacy of Favipiravir Alone and in Combination With Ribavirin in a Lethal, Immunocompetent Mouse Model of Lassa Fever |
title_full_unstemmed | Efficacy of Favipiravir Alone and in Combination With Ribavirin in a Lethal, Immunocompetent Mouse Model of Lassa Fever |
title_short | Efficacy of Favipiravir Alone and in Combination With Ribavirin in a Lethal, Immunocompetent Mouse Model of Lassa Fever |
title_sort | efficacy of favipiravir alone and in combination with ribavirin in a lethal, immunocompetent mouse model of lassa fever |
topic | Major Articles and Brief Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760419/ https://www.ncbi.nlm.nih.gov/pubmed/26531247 http://dx.doi.org/10.1093/infdis/jiv522 |
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