Physiological basis for muscle stiffness and weakness in a knock‐in M1592V mouse model of hyperkalemic periodic paralysis

The mechanisms responsible for the onset and progressive worsening of episodic muscle stiffness and weakness in hyperkalemic periodic paralysis (HyperKPP) are not fully understood. Using a knock‐in HyperKPP mouse model harboring the M1592V Na(V)1.4 channel mutant, we interrogated changes in physiolo...

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Detalles Bibliográficos
Autores principales: Khogali, Shiemaa, Lucas, Brooke, Ammar, Tarek, Dejong, Danica, Barbalinardo, Michael, Hayward, Lawrence J., Renaud, Jean‐Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760441/
https://www.ncbi.nlm.nih.gov/pubmed/26702073
http://dx.doi.org/10.14814/phy2.12656

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760441/
https://www.ncbi.nlm.nih.gov/pubmed/26702073
http://dx.doi.org/10.14814/phy2.12656

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