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Impact of Elevated Hemoglobin and Serum Protein on Vasovagal Reaction from Blood Donation

We conducted a cross-sectional study to elucidate factors contributing to vasovagal reaction (VVR), the most frequent side effect following whole blood and apheresis donations. Complications recorded at the collection sites after voluntary donations by the Japanese Red Cross Tokyo Blood Center (JRC)...

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Autores principales: Odajima, Takeshi, Takanashi, Minoko, Sugimori, Hiroki, Tanba, Taiko, Yoshinaga, Kentaro, Motoji, Toshiko, Munakata, Masaya, Nakajima, Kazunori, Minami, Mutsuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760651/
https://www.ncbi.nlm.nih.gov/pubmed/26894814
http://dx.doi.org/10.1371/journal.pone.0148854
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author Odajima, Takeshi
Takanashi, Minoko
Sugimori, Hiroki
Tanba, Taiko
Yoshinaga, Kentaro
Motoji, Toshiko
Munakata, Masaya
Nakajima, Kazunori
Minami, Mutsuhiko
author_facet Odajima, Takeshi
Takanashi, Minoko
Sugimori, Hiroki
Tanba, Taiko
Yoshinaga, Kentaro
Motoji, Toshiko
Munakata, Masaya
Nakajima, Kazunori
Minami, Mutsuhiko
author_sort Odajima, Takeshi
collection PubMed
description We conducted a cross-sectional study to elucidate factors contributing to vasovagal reaction (VVR), the most frequent side effect following whole blood and apheresis donations. Complications recorded at the collection sites after voluntary donations by the Japanese Red Cross Tokyo Blood Center (JRC), in the 2006 and 2007 fiscal years, were analyzed by both univariate analysis and the multivariate conditional logistic regression model. Of 1,119,716 blood donations over the full two years, complications were recorded for 13,320 donations (1.18%), among which 67% were VVR. There were 4,303 VVR cases which had sufficient information and could be used for this study. For each VVR case, two sex- and age-matched controls (n = 8,606) were randomly selected from the donors without complications. Age, sex, body mass index (BMI), predonation blood pressure, pulse and blood test results, including total protein, albumin, and hemoglobin, were compared between the VVR group and the control group. In univariate analysis, the VVR group was significantly younger, with a lower BMI, higher blood pressure and higher blood protein and hemoglobin levels than the control group (p<0.001). Furthermore, blood protein and hemoglobin levels showed dose-dependent relationships with VVR incidences by the Cochran-Armitage trend test (p<0.01). For both sexes, after adjusting for confounders with the multivariate conditional logistic regression model, the higher than median groups for total protein (male: OR 1.97; 95%CI 1.76,-2.21; female: OR 2.29; 95%CI 2.05–2.56), albumin (male: 1.75; 1.55–1.96; female: 1.76; 1.57–1.97) and hemoglobin (male: 1.98; 1.76–2.22; female: 1.62; 1.45–1.81) had statistically significant higher risk of VVR compared to the lower than median groups. These elevated serum protein and hemoglobin levels might offer new indicators to help understand VVR occurrence.
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spelling pubmed-47606512016-03-07 Impact of Elevated Hemoglobin and Serum Protein on Vasovagal Reaction from Blood Donation Odajima, Takeshi Takanashi, Minoko Sugimori, Hiroki Tanba, Taiko Yoshinaga, Kentaro Motoji, Toshiko Munakata, Masaya Nakajima, Kazunori Minami, Mutsuhiko PLoS One Research Article We conducted a cross-sectional study to elucidate factors contributing to vasovagal reaction (VVR), the most frequent side effect following whole blood and apheresis donations. Complications recorded at the collection sites after voluntary donations by the Japanese Red Cross Tokyo Blood Center (JRC), in the 2006 and 2007 fiscal years, were analyzed by both univariate analysis and the multivariate conditional logistic regression model. Of 1,119,716 blood donations over the full two years, complications were recorded for 13,320 donations (1.18%), among which 67% were VVR. There were 4,303 VVR cases which had sufficient information and could be used for this study. For each VVR case, two sex- and age-matched controls (n = 8,606) were randomly selected from the donors without complications. Age, sex, body mass index (BMI), predonation blood pressure, pulse and blood test results, including total protein, albumin, and hemoglobin, were compared between the VVR group and the control group. In univariate analysis, the VVR group was significantly younger, with a lower BMI, higher blood pressure and higher blood protein and hemoglobin levels than the control group (p<0.001). Furthermore, blood protein and hemoglobin levels showed dose-dependent relationships with VVR incidences by the Cochran-Armitage trend test (p<0.01). For both sexes, after adjusting for confounders with the multivariate conditional logistic regression model, the higher than median groups for total protein (male: OR 1.97; 95%CI 1.76,-2.21; female: OR 2.29; 95%CI 2.05–2.56), albumin (male: 1.75; 1.55–1.96; female: 1.76; 1.57–1.97) and hemoglobin (male: 1.98; 1.76–2.22; female: 1.62; 1.45–1.81) had statistically significant higher risk of VVR compared to the lower than median groups. These elevated serum protein and hemoglobin levels might offer new indicators to help understand VVR occurrence. Public Library of Science 2016-02-19 /pmc/articles/PMC4760651/ /pubmed/26894814 http://dx.doi.org/10.1371/journal.pone.0148854 Text en © 2016 Odajima et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Odajima, Takeshi
Takanashi, Minoko
Sugimori, Hiroki
Tanba, Taiko
Yoshinaga, Kentaro
Motoji, Toshiko
Munakata, Masaya
Nakajima, Kazunori
Minami, Mutsuhiko
Impact of Elevated Hemoglobin and Serum Protein on Vasovagal Reaction from Blood Donation
title Impact of Elevated Hemoglobin and Serum Protein on Vasovagal Reaction from Blood Donation
title_full Impact of Elevated Hemoglobin and Serum Protein on Vasovagal Reaction from Blood Donation
title_fullStr Impact of Elevated Hemoglobin and Serum Protein on Vasovagal Reaction from Blood Donation
title_full_unstemmed Impact of Elevated Hemoglobin and Serum Protein on Vasovagal Reaction from Blood Donation
title_short Impact of Elevated Hemoglobin and Serum Protein on Vasovagal Reaction from Blood Donation
title_sort impact of elevated hemoglobin and serum protein on vasovagal reaction from blood donation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760651/
https://www.ncbi.nlm.nih.gov/pubmed/26894814
http://dx.doi.org/10.1371/journal.pone.0148854
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