Cargando…

The clinicopathological significance and ethnic difference of FHIT hypermethylation in non-small-cell lung carcinoma: a meta-analysis and literature review

Emerging evidence indicates that FHIT is a candidate tumor suppressor in many types of tumors including non-small-cell lung carcinoma (NSCLC). However, the prognostic value and correlation between FHIT hypermethylation and clinicopathological characteristics of NSCLC remains unclear. In this report,...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Xiaoyu, Wu, Guannan, Yao, Xuequan, Hou, Gang, Jiang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760666/
https://www.ncbi.nlm.nih.gov/pubmed/26929601
http://dx.doi.org/10.2147/DDDT.S85253
_version_ 1782416886380625920
author Wu, Xiaoyu
Wu, Guannan
Yao, Xuequan
Hou, Gang
Jiang, Feng
author_facet Wu, Xiaoyu
Wu, Guannan
Yao, Xuequan
Hou, Gang
Jiang, Feng
author_sort Wu, Xiaoyu
collection PubMed
description Emerging evidence indicates that FHIT is a candidate tumor suppressor in many types of tumors including non-small-cell lung carcinoma (NSCLC). However, the prognostic value and correlation between FHIT hypermethylation and clinicopathological characteristics of NSCLC remains unclear. In this report, we performed a meta-analysis to evaluate the effects of FHIT hypermethylation on the incidence of NSCLC and clinicopathological characteristics of human NSCLC patients. Final analysis of 1,801 NSCLC patients from 18 eligible studies was performed. FHIT hypermethylation was found to be significantly higher in NSCLC than in normal lung tissue. The pooled odds ratio (OR) from ten studies included 819 NSCLC and 792 normal lung tissues (OR =7.51, 95% confidence interval [CI] =2.98–18.91, P<0.0001). Subgroup analysis based on ethnicity implied that FHIT hypermethylation level was higher in NSCLC tissues than in normal tissues in both Caucasians (P=0.02) and Asians (P<0.0001), indicating that the difference in Asians was much more significant. FHIT hypermethylation was also correlated with sex status, smoking status, as well as pathological types. In addition, patients with FHIT hypermethylation had a lower survival rate than those without (hazard ratio =1.73, 95% CI =1.10–2.71, P=0.02). The results of this meta-analysis suggest that FHIT hypermethylation is associated with an increased risk and poor survival in NSCLC patients. FHIT hypermethylation, which induces the inactivation of FHIT gene, plays an important role in the carcinogenesis and clinical outcome and may serve as a potential diagnostic marker and drug target of NSCLC.
format Online
Article
Text
id pubmed-4760666
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-47606662016-02-29 The clinicopathological significance and ethnic difference of FHIT hypermethylation in non-small-cell lung carcinoma: a meta-analysis and literature review Wu, Xiaoyu Wu, Guannan Yao, Xuequan Hou, Gang Jiang, Feng Drug Des Devel Ther Original Research Emerging evidence indicates that FHIT is a candidate tumor suppressor in many types of tumors including non-small-cell lung carcinoma (NSCLC). However, the prognostic value and correlation between FHIT hypermethylation and clinicopathological characteristics of NSCLC remains unclear. In this report, we performed a meta-analysis to evaluate the effects of FHIT hypermethylation on the incidence of NSCLC and clinicopathological characteristics of human NSCLC patients. Final analysis of 1,801 NSCLC patients from 18 eligible studies was performed. FHIT hypermethylation was found to be significantly higher in NSCLC than in normal lung tissue. The pooled odds ratio (OR) from ten studies included 819 NSCLC and 792 normal lung tissues (OR =7.51, 95% confidence interval [CI] =2.98–18.91, P<0.0001). Subgroup analysis based on ethnicity implied that FHIT hypermethylation level was higher in NSCLC tissues than in normal tissues in both Caucasians (P=0.02) and Asians (P<0.0001), indicating that the difference in Asians was much more significant. FHIT hypermethylation was also correlated with sex status, smoking status, as well as pathological types. In addition, patients with FHIT hypermethylation had a lower survival rate than those without (hazard ratio =1.73, 95% CI =1.10–2.71, P=0.02). The results of this meta-analysis suggest that FHIT hypermethylation is associated with an increased risk and poor survival in NSCLC patients. FHIT hypermethylation, which induces the inactivation of FHIT gene, plays an important role in the carcinogenesis and clinical outcome and may serve as a potential diagnostic marker and drug target of NSCLC. Dove Medical Press 2016-02-15 /pmc/articles/PMC4760666/ /pubmed/26929601 http://dx.doi.org/10.2147/DDDT.S85253 Text en © 2016 Wu et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Wu, Xiaoyu
Wu, Guannan
Yao, Xuequan
Hou, Gang
Jiang, Feng
The clinicopathological significance and ethnic difference of FHIT hypermethylation in non-small-cell lung carcinoma: a meta-analysis and literature review
title The clinicopathological significance and ethnic difference of FHIT hypermethylation in non-small-cell lung carcinoma: a meta-analysis and literature review
title_full The clinicopathological significance and ethnic difference of FHIT hypermethylation in non-small-cell lung carcinoma: a meta-analysis and literature review
title_fullStr The clinicopathological significance and ethnic difference of FHIT hypermethylation in non-small-cell lung carcinoma: a meta-analysis and literature review
title_full_unstemmed The clinicopathological significance and ethnic difference of FHIT hypermethylation in non-small-cell lung carcinoma: a meta-analysis and literature review
title_short The clinicopathological significance and ethnic difference of FHIT hypermethylation in non-small-cell lung carcinoma: a meta-analysis and literature review
title_sort clinicopathological significance and ethnic difference of fhit hypermethylation in non-small-cell lung carcinoma: a meta-analysis and literature review
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760666/
https://www.ncbi.nlm.nih.gov/pubmed/26929601
http://dx.doi.org/10.2147/DDDT.S85253
work_keys_str_mv AT wuxiaoyu theclinicopathologicalsignificanceandethnicdifferenceoffhithypermethylationinnonsmallcelllungcarcinomaametaanalysisandliteraturereview
AT wuguannan theclinicopathologicalsignificanceandethnicdifferenceoffhithypermethylationinnonsmallcelllungcarcinomaametaanalysisandliteraturereview
AT yaoxuequan theclinicopathologicalsignificanceandethnicdifferenceoffhithypermethylationinnonsmallcelllungcarcinomaametaanalysisandliteraturereview
AT hougang theclinicopathologicalsignificanceandethnicdifferenceoffhithypermethylationinnonsmallcelllungcarcinomaametaanalysisandliteraturereview
AT jiangfeng theclinicopathologicalsignificanceandethnicdifferenceoffhithypermethylationinnonsmallcelllungcarcinomaametaanalysisandliteraturereview
AT wuxiaoyu clinicopathologicalsignificanceandethnicdifferenceoffhithypermethylationinnonsmallcelllungcarcinomaametaanalysisandliteraturereview
AT wuguannan clinicopathologicalsignificanceandethnicdifferenceoffhithypermethylationinnonsmallcelllungcarcinomaametaanalysisandliteraturereview
AT yaoxuequan clinicopathologicalsignificanceandethnicdifferenceoffhithypermethylationinnonsmallcelllungcarcinomaametaanalysisandliteraturereview
AT hougang clinicopathologicalsignificanceandethnicdifferenceoffhithypermethylationinnonsmallcelllungcarcinomaametaanalysisandliteraturereview
AT jiangfeng clinicopathologicalsignificanceandethnicdifferenceoffhithypermethylationinnonsmallcelllungcarcinomaametaanalysisandliteraturereview