Antacid Use and De Novo Brain Metastases in Patients with Epidermal Growth Factor Receptor-Mutant Non-Small Cell Lung Cancer Who Were Treated Using First-Line First-Generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors

BACKGROUND: Antacid treatments decrease the serum concentrations of first-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs), although it is unknown whether antacids affect clinical outcomes. As cerebrospinal fluid concentrations of TKIs are much lower than serum co...

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Detalles Bibliográficos
Autores principales: Chen, Yu-Mu, Lai, Chien-Hao, Chang, Huang-Chih, Chao, Tung-Ying, Tseng, Chia-Cheng, Fang, Wen-Feng, Wang, Chin-Chou, Chung, Yu-Hsiu, Wang, Yi-Hsi, Su, Mao-Chang, Liu, Shih-Feng, Huang, Kuo-Tung, Chen, Hung-Chen, Chang, Ya-Chun, Lin, Meng-Chih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760710/
https://www.ncbi.nlm.nih.gov/pubmed/26894507
http://dx.doi.org/10.1371/journal.pone.0149722

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