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Sequential selection of economic good and action in medial frontal cortex of macaques during value-based decisions

Value-based decisions could rely either on the selection of desired economic goods or on the selection of the actions that will obtain the goods. We investigated this question by recording from the supplementary eye field (SEF) of monkeys during a gambling task that allowed us to distinguish chosen...

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Detalles Bibliográficos
Autores principales: Chen, Xiaomo, Stuphorn, Veit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760954/
https://www.ncbi.nlm.nih.gov/pubmed/26613409
http://dx.doi.org/10.7554/eLife.09418
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author Chen, Xiaomo
Stuphorn, Veit
author_facet Chen, Xiaomo
Stuphorn, Veit
author_sort Chen, Xiaomo
collection PubMed
description Value-based decisions could rely either on the selection of desired economic goods or on the selection of the actions that will obtain the goods. We investigated this question by recording from the supplementary eye field (SEF) of monkeys during a gambling task that allowed us to distinguish chosen good from chosen action signals. Analysis of the individual neuron activity, as well as of the population state-space dynamic, showed that SEF encodes first the chosen gamble option (the desired economic good) and only ~100 ms later the saccade that will obtain it (the chosen action). The action selection is likely driven by inhibitory interactions between different SEF neurons. Our results suggest that during value-based decisions, the selection of economic goods precedes and guides the selection of actions. The two selection steps serve different functions and can therefore not compensate for each other, even when information guiding both processes is given simultaneously. DOI: http://dx.doi.org/10.7554/eLife.09418.001
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spelling pubmed-47609542016-02-22 Sequential selection of economic good and action in medial frontal cortex of macaques during value-based decisions Chen, Xiaomo Stuphorn, Veit eLife Neuroscience Value-based decisions could rely either on the selection of desired economic goods or on the selection of the actions that will obtain the goods. We investigated this question by recording from the supplementary eye field (SEF) of monkeys during a gambling task that allowed us to distinguish chosen good from chosen action signals. Analysis of the individual neuron activity, as well as of the population state-space dynamic, showed that SEF encodes first the chosen gamble option (the desired economic good) and only ~100 ms later the saccade that will obtain it (the chosen action). The action selection is likely driven by inhibitory interactions between different SEF neurons. Our results suggest that during value-based decisions, the selection of economic goods precedes and guides the selection of actions. The two selection steps serve different functions and can therefore not compensate for each other, even when information guiding both processes is given simultaneously. DOI: http://dx.doi.org/10.7554/eLife.09418.001 eLife Sciences Publications, Ltd 2015-11-27 /pmc/articles/PMC4760954/ /pubmed/26613409 http://dx.doi.org/10.7554/eLife.09418 Text en © 2015, Chen et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Chen, Xiaomo
Stuphorn, Veit
Sequential selection of economic good and action in medial frontal cortex of macaques during value-based decisions
title Sequential selection of economic good and action in medial frontal cortex of macaques during value-based decisions
title_full Sequential selection of economic good and action in medial frontal cortex of macaques during value-based decisions
title_fullStr Sequential selection of economic good and action in medial frontal cortex of macaques during value-based decisions
title_full_unstemmed Sequential selection of economic good and action in medial frontal cortex of macaques during value-based decisions
title_short Sequential selection of economic good and action in medial frontal cortex of macaques during value-based decisions
title_sort sequential selection of economic good and action in medial frontal cortex of macaques during value-based decisions
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760954/
https://www.ncbi.nlm.nih.gov/pubmed/26613409
http://dx.doi.org/10.7554/eLife.09418
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