Functioning of drug-metabolizing microsomal cytochrome P450s: In silico probing of proteins suggests that the distal heme ‘active site’ pocket plays a relatively ‘passive role’ in some enzyme-substrate interactions

PURPOSE: The currently held mechanistic understanding of microsomal cytochrome P450s (CYPs) seeks that diverse drug molecules bind within the deep-seated distal heme pocket and subsequently react at the heme centre. To explain a bevy of experimental observations and meta-analyses, we indulge a hypot...

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Detalles Bibliográficos
Autores principales: Venkatachalam, Avanthika, Parashar, Abhinav, Manoj, Kelath Murali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760962/
https://www.ncbi.nlm.nih.gov/pubmed/26894412
http://dx.doi.org/10.1186/s40203-016-0016-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760962/
https://www.ncbi.nlm.nih.gov/pubmed/26894412
http://dx.doi.org/10.1186/s40203-016-0016-7

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