The UniProtKB guide to the human proteome

Advances in high-throughput and advanced technologies allow researchers to routinely perform whole genome and proteome analysis. For this purpose, they need high-quality resources providing comprehensive gene and protein sets for their organisms of interest. Using the example of the human proteome,...

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Autores principales: Breuza, Lionel, Poux, Sylvain, Estreicher, Anne, Famiglietti, Maria Livia, Magrane, Michele, Tognolli, Michael, Bridge, Alan, Baratin, Delphine, Redaschi, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761109/
https://www.ncbi.nlm.nih.gov/pubmed/26896845
http://dx.doi.org/10.1093/database/bav120
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author Breuza, Lionel
Poux, Sylvain
Estreicher, Anne
Famiglietti, Maria Livia
Magrane, Michele
Tognolli, Michael
Bridge, Alan
Baratin, Delphine
Redaschi, Nicole
author_facet Breuza, Lionel
Poux, Sylvain
Estreicher, Anne
Famiglietti, Maria Livia
Magrane, Michele
Tognolli, Michael
Bridge, Alan
Baratin, Delphine
Redaschi, Nicole
author_sort Breuza, Lionel
collection PubMed
description Advances in high-throughput and advanced technologies allow researchers to routinely perform whole genome and proteome analysis. For this purpose, they need high-quality resources providing comprehensive gene and protein sets for their organisms of interest. Using the example of the human proteome, we will describe the content of a complete proteome in the UniProt Knowledgebase (UniProtKB). We will show how manual expert curation of UniProtKB/Swiss-Prot is complemented by expert-driven automatic annotation to build a comprehensive, high-quality and traceable resource. We will also illustrate how the complexity of the human proteome is captured and structured in UniProtKB. Database URL: www.uniprot.org
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spelling pubmed-47611092016-02-22 The UniProtKB guide to the human proteome Breuza, Lionel Poux, Sylvain Estreicher, Anne Famiglietti, Maria Livia Magrane, Michele Tognolli, Michael Bridge, Alan Baratin, Delphine Redaschi, Nicole Database (Oxford) Original Article Advances in high-throughput and advanced technologies allow researchers to routinely perform whole genome and proteome analysis. For this purpose, they need high-quality resources providing comprehensive gene and protein sets for their organisms of interest. Using the example of the human proteome, we will describe the content of a complete proteome in the UniProt Knowledgebase (UniProtKB). We will show how manual expert curation of UniProtKB/Swiss-Prot is complemented by expert-driven automatic annotation to build a comprehensive, high-quality and traceable resource. We will also illustrate how the complexity of the human proteome is captured and structured in UniProtKB. Database URL: www.uniprot.org Oxford University Press 2016-02-19 /pmc/articles/PMC4761109/ /pubmed/26896845 http://dx.doi.org/10.1093/database/bav120 Text en © The Author(s) 2016. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Breuza, Lionel
Poux, Sylvain
Estreicher, Anne
Famiglietti, Maria Livia
Magrane, Michele
Tognolli, Michael
Bridge, Alan
Baratin, Delphine
Redaschi, Nicole
The UniProtKB guide to the human proteome
title The UniProtKB guide to the human proteome
title_full The UniProtKB guide to the human proteome
title_fullStr The UniProtKB guide to the human proteome
title_full_unstemmed The UniProtKB guide to the human proteome
title_short The UniProtKB guide to the human proteome
title_sort uniprotkb guide to the human proteome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761109/
https://www.ncbi.nlm.nih.gov/pubmed/26896845
http://dx.doi.org/10.1093/database/bav120
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