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RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer

Factors linking inflammation and cancer are of great interest. We now report that the chromatin-targeting E3 ubiquitin ligase RNF20/RNF40, driving histone H2B monoubiquitylation (H2Bub1), modulates inflammation and inflammation-associated cancer in mice and humans. Downregulation of RNF20 and H2Bub1...

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Detalles Bibliográficos
Autores principales:	Tarcic, Ohad, Pateras, Ioannis S., Cooks, Tomer, Shema, Efrat, Kanterman, Julia, Ashkenazi, Hadas, Boocholez, Hana, Hubert, Ayala, Rotkopf, Ron, Baniyash, Michal, Pikarsky, Eli, Gorgoulis, Vassilis G., Oren, Moshe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761112/ https://www.ncbi.nlm.nih.gov/pubmed/26854224 http://dx.doi.org/10.1016/j.celrep.2016.01.020

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