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Salivary oxidant/ antioxidant status and hematological parameters in patients with recurrent aphthous stomatitis

BACKGROUND: Recurrent aphthous stomatitis (RAS) is the most common inflammatory ulcerative condition of oral cavity. The aim of this study was to compare the levels of the salivary Malondialdehyde (MDA) and total antioxidant capacity (TAC) and blood parameter in RAS versus healthy controls. METHODS:...

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Autores principales: Babaee, Neda, Hosseinkazemi, Hamed, Pouramir, Mahdi, Khakbaz Baboli, Oveis, Salehi, Maede, Khadir, Fatemeh, Bijani, Ali, Mehryari, Mahsa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Babol University of Medical Sciences 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761117/
https://www.ncbi.nlm.nih.gov/pubmed/26958327
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author Babaee, Neda
Hosseinkazemi, Hamed
Pouramir, Mahdi
Khakbaz Baboli, Oveis
Salehi, Maede
Khadir, Fatemeh
Bijani, Ali
Mehryari, Mahsa
author_facet Babaee, Neda
Hosseinkazemi, Hamed
Pouramir, Mahdi
Khakbaz Baboli, Oveis
Salehi, Maede
Khadir, Fatemeh
Bijani, Ali
Mehryari, Mahsa
author_sort Babaee, Neda
collection PubMed
description BACKGROUND: Recurrent aphthous stomatitis (RAS) is the most common inflammatory ulcerative condition of oral cavity. The aim of this study was to compare the levels of the salivary Malondialdehyde (MDA) and total antioxidant capacity (TAC) and blood parameter in RAS versus healthy controls. METHODS: This case-control study consisted of 28 patients with RAS and 28 age and sex -matched control without RAS. Cell blood count was assessed by sysmex system, serum iron and total iron binding capacity was measured by standard laboratory kit and for ferritin ELISA kit was utilized. Salivary TAC and MDA level determined using FRAP and TBARS method respectively. Statistical analysis was performed using SPSS Version 21, chi-square test was used to compare proportions, and student’s t-test and Mann Whitney U-test were used for the comparison of quantitative variables RESULTS: Salivary MDA level was significantly higher (p<0.001) and TAC level was significantly lower (p<0.042) in RAS as compared with the control group. Also, serum ferritin level was significantly higher in RAS patients (p<0.008). CONCLUSION: These findings indicate the alteration of oxidant/antioxidant status was observed in recurrent aphthous stomatitis, may be also associated with changing several hematinic parameters in this study. The finding maybe helpful to clarify the etiologies of RAS and possibely to improve the management or preventive options.
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spelling pubmed-47611172016-03-08 Salivary oxidant/ antioxidant status and hematological parameters in patients with recurrent aphthous stomatitis Babaee, Neda Hosseinkazemi, Hamed Pouramir, Mahdi Khakbaz Baboli, Oveis Salehi, Maede Khadir, Fatemeh Bijani, Ali Mehryari, Mahsa Caspian J Intern Med Original Article BACKGROUND: Recurrent aphthous stomatitis (RAS) is the most common inflammatory ulcerative condition of oral cavity. The aim of this study was to compare the levels of the salivary Malondialdehyde (MDA) and total antioxidant capacity (TAC) and blood parameter in RAS versus healthy controls. METHODS: This case-control study consisted of 28 patients with RAS and 28 age and sex -matched control without RAS. Cell blood count was assessed by sysmex system, serum iron and total iron binding capacity was measured by standard laboratory kit and for ferritin ELISA kit was utilized. Salivary TAC and MDA level determined using FRAP and TBARS method respectively. Statistical analysis was performed using SPSS Version 21, chi-square test was used to compare proportions, and student’s t-test and Mann Whitney U-test were used for the comparison of quantitative variables RESULTS: Salivary MDA level was significantly higher (p<0.001) and TAC level was significantly lower (p<0.042) in RAS as compared with the control group. Also, serum ferritin level was significantly higher in RAS patients (p<0.008). CONCLUSION: These findings indicate the alteration of oxidant/antioxidant status was observed in recurrent aphthous stomatitis, may be also associated with changing several hematinic parameters in this study. The finding maybe helpful to clarify the etiologies of RAS and possibely to improve the management or preventive options. Babol University of Medical Sciences 2016 /pmc/articles/PMC4761117/ /pubmed/26958327 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Babaee, Neda
Hosseinkazemi, Hamed
Pouramir, Mahdi
Khakbaz Baboli, Oveis
Salehi, Maede
Khadir, Fatemeh
Bijani, Ali
Mehryari, Mahsa
Salivary oxidant/ antioxidant status and hematological parameters in patients with recurrent aphthous stomatitis
title Salivary oxidant/ antioxidant status and hematological parameters in patients with recurrent aphthous stomatitis
title_full Salivary oxidant/ antioxidant status and hematological parameters in patients with recurrent aphthous stomatitis
title_fullStr Salivary oxidant/ antioxidant status and hematological parameters in patients with recurrent aphthous stomatitis
title_full_unstemmed Salivary oxidant/ antioxidant status and hematological parameters in patients with recurrent aphthous stomatitis
title_short Salivary oxidant/ antioxidant status and hematological parameters in patients with recurrent aphthous stomatitis
title_sort salivary oxidant/ antioxidant status and hematological parameters in patients with recurrent aphthous stomatitis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761117/
https://www.ncbi.nlm.nih.gov/pubmed/26958327
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