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Molecular basis of contact inhibition of locomotion

Contact inhibition of locomotion (CIL) is a complex process, whereby cells undergoing a collision with another cell cease their migration towards the colliding cell. CIL has been identified in numerous cells during development including embryonic fibroblasts, neural crest cells and haemocytes and is...

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Detalles Bibliográficos
Autores principales: Roycroft, Alice, Mayor, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761371/
https://www.ncbi.nlm.nih.gov/pubmed/26585026
http://dx.doi.org/10.1007/s00018-015-2090-0
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author Roycroft, Alice
Mayor, Roberto
author_facet Roycroft, Alice
Mayor, Roberto
author_sort Roycroft, Alice
collection PubMed
description Contact inhibition of locomotion (CIL) is a complex process, whereby cells undergoing a collision with another cell cease their migration towards the colliding cell. CIL has been identified in numerous cells during development including embryonic fibroblasts, neural crest cells and haemocytes and is the driving force behind a range of phenomenon including collective cell migration and dispersion. The loss of normal CIL behaviour towards healthy tissue has long been implicated in the invasion of cancer cells. CIL is a multi-step process that is driven by the tight coordination of molecular machinery. In this review, we shall breakdown CIL into distinct steps and highlight the key molecular mechanisms and components that are involved in driving each step of this process.
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spelling pubmed-47613712016-03-01 Molecular basis of contact inhibition of locomotion Roycroft, Alice Mayor, Roberto Cell Mol Life Sci Review Contact inhibition of locomotion (CIL) is a complex process, whereby cells undergoing a collision with another cell cease their migration towards the colliding cell. CIL has been identified in numerous cells during development including embryonic fibroblasts, neural crest cells and haemocytes and is the driving force behind a range of phenomenon including collective cell migration and dispersion. The loss of normal CIL behaviour towards healthy tissue has long been implicated in the invasion of cancer cells. CIL is a multi-step process that is driven by the tight coordination of molecular machinery. In this review, we shall breakdown CIL into distinct steps and highlight the key molecular mechanisms and components that are involved in driving each step of this process. Springer International Publishing 2015-11-19 2016 /pmc/articles/PMC4761371/ /pubmed/26585026 http://dx.doi.org/10.1007/s00018-015-2090-0 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Roycroft, Alice
Mayor, Roberto
Molecular basis of contact inhibition of locomotion
title Molecular basis of contact inhibition of locomotion
title_full Molecular basis of contact inhibition of locomotion
title_fullStr Molecular basis of contact inhibition of locomotion
title_full_unstemmed Molecular basis of contact inhibition of locomotion
title_short Molecular basis of contact inhibition of locomotion
title_sort molecular basis of contact inhibition of locomotion
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761371/
https://www.ncbi.nlm.nih.gov/pubmed/26585026
http://dx.doi.org/10.1007/s00018-015-2090-0
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