Capecitabine Induced Multifocal Leukoencephalopathy: Do We Have Always to Switch off the Chemotherapy?

Capecitabine is a well tolerated and safe 5-fluorouracil agent for adjuvant, neoadjuvant chemotherapy or metastatic cases. Neurological side effects require discontinuation of chemotherapy. We report this unique case of a 50-year-old female, who presented an isolated episode of dysarthria and ataxia...

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Autores principales: Bougea, Anastasia, Voskou, Panagiota, Kilidireas, Constantinos, Andreadou, Elisabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761382/
https://www.ncbi.nlm.nih.gov/pubmed/26966603
http://dx.doi.org/10.1155/2016/2408269
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author Bougea, Anastasia
Voskou, Panagiota
Kilidireas, Constantinos
Andreadou, Elisabeth
author_facet Bougea, Anastasia
Voskou, Panagiota
Kilidireas, Constantinos
Andreadou, Elisabeth
author_sort Bougea, Anastasia
collection PubMed
description Capecitabine is a well tolerated and safe 5-fluorouracil agent for adjuvant, neoadjuvant chemotherapy or metastatic cases. Neurological side effects require discontinuation of chemotherapy. We report this unique case of a 50-year-old female, who presented an isolated episode of dysarthria and ataxia under bevacizumab, capecitabine, and oxaliplatin treatment due to reversible multifocal leukoencephalopathy that did not recur after readministration of chemotherapy.
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spelling pubmed-47613822016-03-10 Capecitabine Induced Multifocal Leukoencephalopathy: Do We Have Always to Switch off the Chemotherapy? Bougea, Anastasia Voskou, Panagiota Kilidireas, Constantinos Andreadou, Elisabeth Case Rep Oncol Med Case Report Capecitabine is a well tolerated and safe 5-fluorouracil agent for adjuvant, neoadjuvant chemotherapy or metastatic cases. Neurological side effects require discontinuation of chemotherapy. We report this unique case of a 50-year-old female, who presented an isolated episode of dysarthria and ataxia under bevacizumab, capecitabine, and oxaliplatin treatment due to reversible multifocal leukoencephalopathy that did not recur after readministration of chemotherapy. Hindawi Publishing Corporation 2016 2016-02-07 /pmc/articles/PMC4761382/ /pubmed/26966603 http://dx.doi.org/10.1155/2016/2408269 Text en Copyright © 2016 Anastasia Bougea et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Bougea, Anastasia
Voskou, Panagiota
Kilidireas, Constantinos
Andreadou, Elisabeth
Capecitabine Induced Multifocal Leukoencephalopathy: Do We Have Always to Switch off the Chemotherapy?
title Capecitabine Induced Multifocal Leukoencephalopathy: Do We Have Always to Switch off the Chemotherapy?
title_full Capecitabine Induced Multifocal Leukoencephalopathy: Do We Have Always to Switch off the Chemotherapy?
title_fullStr Capecitabine Induced Multifocal Leukoencephalopathy: Do We Have Always to Switch off the Chemotherapy?
title_full_unstemmed Capecitabine Induced Multifocal Leukoencephalopathy: Do We Have Always to Switch off the Chemotherapy?
title_short Capecitabine Induced Multifocal Leukoencephalopathy: Do We Have Always to Switch off the Chemotherapy?
title_sort capecitabine induced multifocal leukoencephalopathy: do we have always to switch off the chemotherapy?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761382/
https://www.ncbi.nlm.nih.gov/pubmed/26966603
http://dx.doi.org/10.1155/2016/2408269
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