Selective Bottlenecks Shape Evolutionary Pathways Taken during Mammalian Adaptation of a 1918-like Avian Influenza Virus

Avian influenza virus reassortants resembling the 1918 human pandemic virus can become transmissible among mammals by acquiring mutations in hemagglutinin (HA) and polymerase. Using the ferret model, we trace the evolutionary pathway by which an avian-like virus evolves the capacity for mammalian re...

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Detalles Bibliográficos
Autores principales: Moncla, Louise H., Zhong, Gongxun, Nelson, Chase W., Dinis, Jorge M., Mutschler, James, Hughes, Austin L., Watanabe, Tokiko, Kawaoka, Yoshihiro, Friedrich, Thomas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761429/
https://www.ncbi.nlm.nih.gov/pubmed/26867176
http://dx.doi.org/10.1016/j.chom.2016.01.011

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