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Comorbidity Factors and Brain Mechanisms Linking Chronic Stress and Systemic Illness
Neuropsychiatric symptoms and mental illness are commonly present in patients with chronic systemic diseases. Mood disorders, such as depression, are present in up to 50% of these patients, resulting in impaired physical recovery and more intricate treatment regimen. Stress associated with both phys...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761674/ https://www.ncbi.nlm.nih.gov/pubmed/26977323 http://dx.doi.org/10.1155/2016/5460732 |
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author | Duric, Vanja Clayton, Sarah Leong, Mai Lan Yuan, Li-Lian |
author_facet | Duric, Vanja Clayton, Sarah Leong, Mai Lan Yuan, Li-Lian |
author_sort | Duric, Vanja |
collection | PubMed |
description | Neuropsychiatric symptoms and mental illness are commonly present in patients with chronic systemic diseases. Mood disorders, such as depression, are present in up to 50% of these patients, resulting in impaired physical recovery and more intricate treatment regimen. Stress associated with both physical and emotional aspects of systemic illness is thought to elicit detrimental effects to initiate comorbid mental disorders. However, clinical reports also indicate that the relationship between systemic and psychiatric illnesses is bidirectional, further increasing the complexity of the underlying pathophysiological processes. In this review, we discuss the recent evidence linking chronic stress and systemic illness, such as activation of the immune response system and release of common proinflammatory mediators. Altogether, discovery of new targets is needed for development of better treatments for stress-related psychiatric illnesses as well as improvement of mental health aspects of different systemic diseases. |
format | Online Article Text |
id | pubmed-4761674 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-47616742016-03-14 Comorbidity Factors and Brain Mechanisms Linking Chronic Stress and Systemic Illness Duric, Vanja Clayton, Sarah Leong, Mai Lan Yuan, Li-Lian Neural Plast Review Article Neuropsychiatric symptoms and mental illness are commonly present in patients with chronic systemic diseases. Mood disorders, such as depression, are present in up to 50% of these patients, resulting in impaired physical recovery and more intricate treatment regimen. Stress associated with both physical and emotional aspects of systemic illness is thought to elicit detrimental effects to initiate comorbid mental disorders. However, clinical reports also indicate that the relationship between systemic and psychiatric illnesses is bidirectional, further increasing the complexity of the underlying pathophysiological processes. In this review, we discuss the recent evidence linking chronic stress and systemic illness, such as activation of the immune response system and release of common proinflammatory mediators. Altogether, discovery of new targets is needed for development of better treatments for stress-related psychiatric illnesses as well as improvement of mental health aspects of different systemic diseases. Hindawi Publishing Corporation 2016 2016-02-08 /pmc/articles/PMC4761674/ /pubmed/26977323 http://dx.doi.org/10.1155/2016/5460732 Text en Copyright © 2016 Vanja Duric et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Duric, Vanja Clayton, Sarah Leong, Mai Lan Yuan, Li-Lian Comorbidity Factors and Brain Mechanisms Linking Chronic Stress and Systemic Illness |
title | Comorbidity Factors and Brain Mechanisms Linking Chronic Stress and Systemic Illness |
title_full | Comorbidity Factors and Brain Mechanisms Linking Chronic Stress and Systemic Illness |
title_fullStr | Comorbidity Factors and Brain Mechanisms Linking Chronic Stress and Systemic Illness |
title_full_unstemmed | Comorbidity Factors and Brain Mechanisms Linking Chronic Stress and Systemic Illness |
title_short | Comorbidity Factors and Brain Mechanisms Linking Chronic Stress and Systemic Illness |
title_sort | comorbidity factors and brain mechanisms linking chronic stress and systemic illness |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761674/ https://www.ncbi.nlm.nih.gov/pubmed/26977323 http://dx.doi.org/10.1155/2016/5460732 |
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