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Adipose-Derived Stem Cells for Tissue Engineering and Regenerative Medicine Applications

Adipose-derived stem cells (ASCs) are a mesenchymal stem cell source with properties of self-renewal and multipotential differentiation. Compared to bone marrow-derived stem cells (BMSCs), ASCs can be derived from more sources and are harvested more easily. Three-dimensional (3D) tissue engineering...

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Detalles Bibliográficos
Autores principales: Dai, Ru, Wang, Zongjie, Samanipour, Roya, Koo, Kyo-in, Kim, Keekyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761677/
https://www.ncbi.nlm.nih.gov/pubmed/27057174
http://dx.doi.org/10.1155/2016/6737345
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author Dai, Ru
Wang, Zongjie
Samanipour, Roya
Koo, Kyo-in
Kim, Keekyoung
author_facet Dai, Ru
Wang, Zongjie
Samanipour, Roya
Koo, Kyo-in
Kim, Keekyoung
author_sort Dai, Ru
collection PubMed
description Adipose-derived stem cells (ASCs) are a mesenchymal stem cell source with properties of self-renewal and multipotential differentiation. Compared to bone marrow-derived stem cells (BMSCs), ASCs can be derived from more sources and are harvested more easily. Three-dimensional (3D) tissue engineering scaffolds are better able to mimic the in vivo cellular microenvironment, which benefits the localization, attachment, proliferation, and differentiation of ASCs. Therefore, tissue-engineered ASCs are recognized as an attractive substitute for tissue and organ transplantation. In this paper, we review the characteristics of ASCs, as well as the biomaterials and tissue engineering methods used to proliferate and differentiate ASCs in a 3D environment. Clinical applications of tissue-engineered ASCs are also discussed to reveal the potential and feasibility of using tissue-engineered ASCs in regenerative medicine.
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spelling pubmed-47616772016-04-07 Adipose-Derived Stem Cells for Tissue Engineering and Regenerative Medicine Applications Dai, Ru Wang, Zongjie Samanipour, Roya Koo, Kyo-in Kim, Keekyoung Stem Cells Int Review Article Adipose-derived stem cells (ASCs) are a mesenchymal stem cell source with properties of self-renewal and multipotential differentiation. Compared to bone marrow-derived stem cells (BMSCs), ASCs can be derived from more sources and are harvested more easily. Three-dimensional (3D) tissue engineering scaffolds are better able to mimic the in vivo cellular microenvironment, which benefits the localization, attachment, proliferation, and differentiation of ASCs. Therefore, tissue-engineered ASCs are recognized as an attractive substitute for tissue and organ transplantation. In this paper, we review the characteristics of ASCs, as well as the biomaterials and tissue engineering methods used to proliferate and differentiate ASCs in a 3D environment. Clinical applications of tissue-engineered ASCs are also discussed to reveal the potential and feasibility of using tissue-engineered ASCs in regenerative medicine. Hindawi Publishing Corporation 2016 2016-02-21 /pmc/articles/PMC4761677/ /pubmed/27057174 http://dx.doi.org/10.1155/2016/6737345 Text en Copyright © 2016 Ru Dai et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Dai, Ru
Wang, Zongjie
Samanipour, Roya
Koo, Kyo-in
Kim, Keekyoung
Adipose-Derived Stem Cells for Tissue Engineering and Regenerative Medicine Applications
title Adipose-Derived Stem Cells for Tissue Engineering and Regenerative Medicine Applications
title_full Adipose-Derived Stem Cells for Tissue Engineering and Regenerative Medicine Applications
title_fullStr Adipose-Derived Stem Cells for Tissue Engineering and Regenerative Medicine Applications
title_full_unstemmed Adipose-Derived Stem Cells for Tissue Engineering and Regenerative Medicine Applications
title_short Adipose-Derived Stem Cells for Tissue Engineering and Regenerative Medicine Applications
title_sort adipose-derived stem cells for tissue engineering and regenerative medicine applications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761677/
https://www.ncbi.nlm.nih.gov/pubmed/27057174
http://dx.doi.org/10.1155/2016/6737345
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