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Nerves Control Redox Levels in Mature Tissues Through Schwann Cells and Hedgehog Signaling

Aims: Recent advances in redox biology have emphasized the role of hydrogen peroxide (H(2)O(2)) in the modulation of signaling pathways and revealed that H(2)O(2) plays a role in cellular remodeling in adults. Thus, an understanding of the mechanisms that control H(2)O(2) levels in mature tissue wou...

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Autores principales: Meda, Francesca, Gauron, Carole, Rampon, Christine, Teillon, Jérémie, Volovitch, Michel, Vriz, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761803/
https://www.ncbi.nlm.nih.gov/pubmed/26442784
http://dx.doi.org/10.1089/ars.2015.6380
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author Meda, Francesca
Gauron, Carole
Rampon, Christine
Teillon, Jérémie
Volovitch, Michel
Vriz, Sophie
author_facet Meda, Francesca
Gauron, Carole
Rampon, Christine
Teillon, Jérémie
Volovitch, Michel
Vriz, Sophie
author_sort Meda, Francesca
collection PubMed
description Aims: Recent advances in redox biology have emphasized the role of hydrogen peroxide (H(2)O(2)) in the modulation of signaling pathways and revealed that H(2)O(2) plays a role in cellular remodeling in adults. Thus, an understanding of the mechanisms that control H(2)O(2) levels in mature tissue would be of great interest. Results: We used a denervation strategy to demonstrate that sensory neurons are responsible for controlling H(2)O(2) levels under normal conditions and after being lesioned. Moreover, we demonstrate that severed nerves respond to appendage amputation via the induction of Hedgehog signaling and that this signaling is responsible for H(2)O(2) production in the wounded epidermis. Finally, we show that H(2)O(2) and nerve growth are regulated via reciprocal action in adults. Innovation and Conclusion: These data support a new paradigm for the regulation of tissue homeostasis: H(2)O(2) attracts nerves and nerves control H(2)O(2) levels in a positive feedback loop. This finding suggests that the peripheral nerve redox environment could be a target for manipulating cell plasticity in adults. Antioxid. Redox Signal. 24, 299–311.
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spelling pubmed-47618032016-02-23 Nerves Control Redox Levels in Mature Tissues Through Schwann Cells and Hedgehog Signaling Meda, Francesca Gauron, Carole Rampon, Christine Teillon, Jérémie Volovitch, Michel Vriz, Sophie Antioxid Redox Signal Original Research Communications Aims: Recent advances in redox biology have emphasized the role of hydrogen peroxide (H(2)O(2)) in the modulation of signaling pathways and revealed that H(2)O(2) plays a role in cellular remodeling in adults. Thus, an understanding of the mechanisms that control H(2)O(2) levels in mature tissue would be of great interest. Results: We used a denervation strategy to demonstrate that sensory neurons are responsible for controlling H(2)O(2) levels under normal conditions and after being lesioned. Moreover, we demonstrate that severed nerves respond to appendage amputation via the induction of Hedgehog signaling and that this signaling is responsible for H(2)O(2) production in the wounded epidermis. Finally, we show that H(2)O(2) and nerve growth are regulated via reciprocal action in adults. Innovation and Conclusion: These data support a new paradigm for the regulation of tissue homeostasis: H(2)O(2) attracts nerves and nerves control H(2)O(2) levels in a positive feedback loop. This finding suggests that the peripheral nerve redox environment could be a target for manipulating cell plasticity in adults. Antioxid. Redox Signal. 24, 299–311. Mary Ann Liebert, Inc. 2016-02-20 /pmc/articles/PMC4761803/ /pubmed/26442784 http://dx.doi.org/10.1089/ars.2015.6380 Text en © Francesca Meda et al. 2015; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Research Communications
Meda, Francesca
Gauron, Carole
Rampon, Christine
Teillon, Jérémie
Volovitch, Michel
Vriz, Sophie
Nerves Control Redox Levels in Mature Tissues Through Schwann Cells and Hedgehog Signaling
title Nerves Control Redox Levels in Mature Tissues Through Schwann Cells and Hedgehog Signaling
title_full Nerves Control Redox Levels in Mature Tissues Through Schwann Cells and Hedgehog Signaling
title_fullStr Nerves Control Redox Levels in Mature Tissues Through Schwann Cells and Hedgehog Signaling
title_full_unstemmed Nerves Control Redox Levels in Mature Tissues Through Schwann Cells and Hedgehog Signaling
title_short Nerves Control Redox Levels in Mature Tissues Through Schwann Cells and Hedgehog Signaling
title_sort nerves control redox levels in mature tissues through schwann cells and hedgehog signaling
topic Original Research Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761803/
https://www.ncbi.nlm.nih.gov/pubmed/26442784
http://dx.doi.org/10.1089/ars.2015.6380
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