Cargando…

Mammalian interspecies substitution of immune modulatory alleles by genome editing

We describe a fundamentally novel feat of animal genetic engineering: the precise and efficient substitution of an agronomic haplotype into a domesticated species. Zinc finger nuclease in-embryo editing of the RELA locus generated live born domestic pigs with the warthog RELA orthologue, associated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lillico, Simon G., Proudfoot, Chris, King, Tim J., Tan, Wenfang, Zhang, Lei, Mardjuki, Rachel, Paschon, David E., Rebar, Edward J., Urnov, Fyodor D., Mileham, Alan J., McLaren, David G., Whitelaw, C. Bruce A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761920/ https://www.ncbi.nlm.nih.gov/pubmed/26898342 http://dx.doi.org/10.1038/srep21645

Ejemplares similares

Live pigs produced from genome edited zygotes
por: Lillico, Simon G., et al.
Publicado: (2013)

Genome edited sheep and cattle
por: Proudfoot, Chris, et al.
Publicado: (2014)

Gene targeting, genome editing: from Dolly to editors
por: Tan, Wenfang, et al.
Publicado: (2016)

Comparison of CRISPR/Cas9 and TALENs on editing an integrated EGFP gene in the genome of HEK293FT cells
por: He, Zuyong, et al.
Publicado: (2016)

Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function
por: Burkard, Christine, et al.
Publicado: (2017)

Dissection of Splicing Regulation at an Endogenous Locus by Zinc-Finger Nuclease-Mediated Gene Editing
por: Cristea, Sandra, et al.
Publicado: (2011)

Blastocyst complementation and interspecies chimeras in gene edited pigs
por: Choe, Yong-ho, et al.
Publicado: (2022)

Genome editing for disease resistance in pigs and chickens
por: Proudfoot, Chris, et al.
Publicado: (2019)

SARS-Cov2 Clinical Diagnostics: Academic Scientists Take on the COVID-19 Pandemic
por: Urnov, Fyodor
Publicado: (2020)

Generation of germline ablated male pigs by CRISPR/Cas9 editing of the NANOS2 gene
por: Park, Ki-Eun, et al.
Publicado: (2017)

Potential of gene drives with genome editing to increase genetic gain in livestock breeding programs
por: Gonen, Serap, et al.
Publicado: (2017)

Pigs Lacking the Scavenger Receptor Cysteine-Rich Domain 5 of CD163 Are Resistant to Porcine Reproductive and Respiratory Syndrome Virus 1 Infection
por: Burkard, Christine, et al.
Publicado: (2018)

Erratum for Burkard et al., “Pigs Lacking the Scavenger Receptor Cysteine-Rich Domain 5 of CD163 Are Resistant to Porcine Reproductive and Respiratory Syndrome Virus 1 Infection”
por: Burkard, Christine, et al.
Publicado: (2020)

Molecular Markers for Interspecies Transmission of Avian Influenza Viruses in Mammalian Hosts
por: Lloren, Khristine Kaith S., et al.
Publicado: (2017)

THE MAMMALIAN CELL-VIRUS RELATIONSHIP : II. ADSORPTION, RECEPTION, AND ECLIPSE OF POLIOVIRUS BY HELA CELLS
por: Holland, John J., et al.
Publicado: (1959)

A multifunctional system for genome editing and large-scale interspecies gene transfer
por: Teufel, Marc, et al.
Publicado: (2022)

Gene expression variation and parental allele inheritance in a Xiphophorus interspecies hybridization model
por: Lu, Yuan, et al.
Publicado: (2018)

Lentiviral vectors containing mouse Csf1r control elements direct macrophage-restricted expression in multiple species of birds and mammals
por: Pridans, Clare, et al.
Publicado: (2014)

Potential of promotion of alleles by genome editing to improve quantitative traits in livestock breeding programs
por: Jenko, Janez, et al.
Publicado: (2015)

A genomic view of experimental intraspecies and interspecies transformation of a rifampicin-resistance allele into Neisseria meningitidis
por: Alfsnes, Kristian, et al.
Publicado: (2018)

THE MAMMALIAN CELL VIRUS RELATIONSHIP : IV. INFECTION OF NATURALLY INSUSCEPTIBLE CELLS WITH ENTEROVIRUS RIBONUCLEIC ACID
por: Holland, John J., et al.
Publicado: (1959)

Erratum to: Potential of promotion of alleles by genome editing to improve quantitative traits in livestock breeding programs
por: Jenko, Janez, et al.
Publicado: (2015)

THE MAMMALIAN CELL-VIRUS RELATIONSHIP : I. ATTACHMENT OF POLIOVIRUS TO CULTIVATED CELLS OF PRIMATE AND NON-PRIMATE ORIGIN
por: McLaren, Leroy C., et al.
Publicado: (1959)

Diversifying the structure of zinc finger nucleases for high-precision genome editing
por: Paschon, David E., et al.
Publicado: (2019)

THE MAMMALIAN CELL-VIRUS RELATIONSHIP : V. SUSCEPTIBILITY AND RESISTANCE OF CELLS IN VITRO TO INFECTION BY COXSACKIE A9 VIRUS
por: McLaren, Leroy C., et al.
Publicado: (1960)

Allele-specific demethylation at an imprinted mammalian promoter
por: Wood, Andrew J., et al.
Publicado: (2007)

Interspecies Organogenesis for Human Transplantation
por: Crane, Andrew T., et al.
Publicado: (2019)

Chlamydiaceae Genomics Reveals Interspecies Admixture and the Recent Evolution of Chlamydia abortus Infecting Lower Mammalian Species and Humans
por: Joseph, Sandeep J., et al.
Publicado: (2015)

Long-Term Engraftment and Fetal Globin Induction upon BCL11A Gene Editing in Bone-Marrow-Derived CD34(+) Hematopoietic Stem and Progenitor Cells
por: Chang, Kai-Hsin, et al.
Publicado: (2017)

In vivo genome editing restores hemostasis in a mouse model of hemophilia
por: Li, Hojun, et al.
Publicado: (2011)

Favoring Expression of Yak Alleles in Interspecies F1 Hybrids of Cattle and Yak Under High-Altitude Environments
por: Chen, Shi-Yi, et al.
Publicado: (2022)

Substitution of warthog NF-κB motifs into RELA of domestic pigs is not sufficient to confer resilience to African swine fever virus
por: McCleary, Stephen, et al.
Publicado: (2020)

Efficient interspecies transmission of synthetic prions
por: Block, Alyssa J., et al.
Publicado: (2021)

Engineering large animal models of human disease
por: Whitelaw, C Bruce A, et al.
Publicado: (2015)

Cell size of alveolar macrophages: an interspecies comparison.
por: Krombach, F, et al.
Publicado: (1997)

Potential for Interspecies Toxicity Estimation in Soil Invertebrates
por: Barron, Mace G., et al.
Publicado: (2021)

Editing DNA Methylation in Mammalian Embryos
por: Yamazaki, Taiga, et al.
Publicado: (2020)

HLA Heterozygote Advantage against HIV-1 Is Driven by Quantitative and Qualitative Differences in HLA Allele-Specific Peptide Presentation
por: Arora, Jatin, et al.
Publicado: (2020)

Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology
por: Orlando, Salvatore J., et al.
Publicado: (2010)

Utilising polymorphisms to achieve allele-specific genome editing in zebrafish
por: Capon, Samuel J., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_qjv0317toro1thm4etfli2verk