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Modulation of E-cadherin expression promotes migration ability of esophageal cancer cells

Losing the E-cadherin plays an important role in the metastasis of cancer. The regulation of the expression of E-cadherin is unclear. Circadian rhythm alteration is associated with the pathogenesis of a number of cancers. This study aims to investigate the role of one of the circadian proteins, peri...

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Autores principales: Li, Shujun, Qin, Xuebo, Chai, Song, Qu, Changbao, Wang, Xiaolu, Zhang, Helin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761978/
https://www.ncbi.nlm.nih.gov/pubmed/26898709
http://dx.doi.org/10.1038/srep21713
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author Li, Shujun
Qin, Xuebo
Chai, Song
Qu, Changbao
Wang, Xiaolu
Zhang, Helin
author_facet Li, Shujun
Qin, Xuebo
Chai, Song
Qu, Changbao
Wang, Xiaolu
Zhang, Helin
author_sort Li, Shujun
collection PubMed
description Losing the E-cadherin plays an important role in the metastasis of cancer. The regulation of the expression of E-cadherin is unclear. Circadian rhythm alteration is associated with the pathogenesis of a number of cancers. This study aims to investigate the role of one of the circadian proteins, period-2 (Per2) in repressing the expression of E-cadherin in esophageal cancer (esophageal cancer). We observed that the levels of circadian protein Per2 were significantly increased and E-cadherin was significantly decreased in the tissue of human esophageal cancer with metastasis as compared with non-metastatic esophageal cancer. Overexpression of Per2 in the esophageal cancer cells markedly repressed the expression of E-cadherin. The pHDAC1 was detected in human esophageal cancer with metastasis, which was much less in the esophageal cancer tissue without metastasis. Overexpression of Per2 increased the levels of pHDAC1 as well as the E-cadherin repressors at the E-cadherin promoter locus. Overexpression of Per2 markedly increased the migratory capacity of esophageal cancer cells, which was abolished by the inhibition of HDAC1. We conclude that Per-2 plays an important role in the esophageal cancer cell metastasis, which may be a novel therapeutic target for the treatment of esophageal cancer.
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spelling pubmed-47619782016-02-29 Modulation of E-cadherin expression promotes migration ability of esophageal cancer cells Li, Shujun Qin, Xuebo Chai, Song Qu, Changbao Wang, Xiaolu Zhang, Helin Sci Rep Article Losing the E-cadherin plays an important role in the metastasis of cancer. The regulation of the expression of E-cadherin is unclear. Circadian rhythm alteration is associated with the pathogenesis of a number of cancers. This study aims to investigate the role of one of the circadian proteins, period-2 (Per2) in repressing the expression of E-cadherin in esophageal cancer (esophageal cancer). We observed that the levels of circadian protein Per2 were significantly increased and E-cadherin was significantly decreased in the tissue of human esophageal cancer with metastasis as compared with non-metastatic esophageal cancer. Overexpression of Per2 in the esophageal cancer cells markedly repressed the expression of E-cadherin. The pHDAC1 was detected in human esophageal cancer with metastasis, which was much less in the esophageal cancer tissue without metastasis. Overexpression of Per2 increased the levels of pHDAC1 as well as the E-cadherin repressors at the E-cadherin promoter locus. Overexpression of Per2 markedly increased the migratory capacity of esophageal cancer cells, which was abolished by the inhibition of HDAC1. We conclude that Per-2 plays an important role in the esophageal cancer cell metastasis, which may be a novel therapeutic target for the treatment of esophageal cancer. Nature Publishing Group 2016-02-22 /pmc/articles/PMC4761978/ /pubmed/26898709 http://dx.doi.org/10.1038/srep21713 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Li, Shujun
Qin, Xuebo
Chai, Song
Qu, Changbao
Wang, Xiaolu
Zhang, Helin
Modulation of E-cadherin expression promotes migration ability of esophageal cancer cells
title Modulation of E-cadherin expression promotes migration ability of esophageal cancer cells
title_full Modulation of E-cadherin expression promotes migration ability of esophageal cancer cells
title_fullStr Modulation of E-cadherin expression promotes migration ability of esophageal cancer cells
title_full_unstemmed Modulation of E-cadherin expression promotes migration ability of esophageal cancer cells
title_short Modulation of E-cadherin expression promotes migration ability of esophageal cancer cells
title_sort modulation of e-cadherin expression promotes migration ability of esophageal cancer cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761978/
https://www.ncbi.nlm.nih.gov/pubmed/26898709
http://dx.doi.org/10.1038/srep21713
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