Induction of site-specific chromosomal translocations in embryonic stem cells by CRISPR/Cas9

Chromosomal translocation is the most common form of chromosomal abnormality and is often associated with congenital genetic disorders, infertility, and cancers. The lack of cellular and animal models for chromosomal translocations, however, has hampered our ability to understand the underlying dise...

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Detalles Bibliográficos
Autores principales: Jiang, Junfeng, Zhang, Li, Zhou, Xingliang, Chen, Xi, Huang, Guanyi, Li, Fengsheng, Wang, Ruizhe, Wu, Nancy, Yan, Youzhen, Tong, Chang, Srivastava, Sankalp, Wang, Yue, Liu, Houqi, Ying, Qi-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761995/
https://www.ncbi.nlm.nih.gov/pubmed/26898344
http://dx.doi.org/10.1038/srep21918

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