Skeletal intramyocellular lipid metabolism and insulin resistance

Lipids stored in skeletal muscle cells are known as intramyocellular lipid (IMCL). Disorders involving IMCL and its causative factor, circulatory free fatty acids (FFAs), induce a toxic state and ultimately result in insulin resistance (IR) in muscle tissue. On the other hand, intramuscular triglyce...

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Autores principales: Li, Yiran, Xu, Shimeng, Zhang, Xuelin, Yi, Zongchun, Cichello, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762133/
https://www.ncbi.nlm.nih.gov/pubmed/26942223
http://dx.doi.org/10.1007/s41048-015-0013-0
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author Li, Yiran
Xu, Shimeng
Zhang, Xuelin
Yi, Zongchun
Cichello, Simon
author_facet Li, Yiran
Xu, Shimeng
Zhang, Xuelin
Yi, Zongchun
Cichello, Simon
author_sort Li, Yiran
collection PubMed
description Lipids stored in skeletal muscle cells are known as intramyocellular lipid (IMCL). Disorders involving IMCL and its causative factor, circulatory free fatty acids (FFAs), induce a toxic state and ultimately result in insulin resistance (IR) in muscle tissue. On the other hand, intramuscular triglyceride (IMTG), the most abundant component of IMCL and an essential energy source for active skeletal muscle, is different from other IMCLs, as it is stored in lipid droplets and plays a pivotal role in skeletal muscle energy homeostasis. This review discusses the association of FFA-induced ectopic lipid accumulation and IR, with specific emphasis on the relationship between IMCL/IMTG metabolism and IR.
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spelling pubmed-47621332016-03-01 Skeletal intramyocellular lipid metabolism and insulin resistance Li, Yiran Xu, Shimeng Zhang, Xuelin Yi, Zongchun Cichello, Simon Biophys Rep Methods Lipids stored in skeletal muscle cells are known as intramyocellular lipid (IMCL). Disorders involving IMCL and its causative factor, circulatory free fatty acids (FFAs), induce a toxic state and ultimately result in insulin resistance (IR) in muscle tissue. On the other hand, intramuscular triglyceride (IMTG), the most abundant component of IMCL and an essential energy source for active skeletal muscle, is different from other IMCLs, as it is stored in lipid droplets and plays a pivotal role in skeletal muscle energy homeostasis. This review discusses the association of FFA-induced ectopic lipid accumulation and IR, with specific emphasis on the relationship between IMCL/IMTG metabolism and IR. Springer Berlin Heidelberg 2015-10-23 2015 /pmc/articles/PMC4762133/ /pubmed/26942223 http://dx.doi.org/10.1007/s41048-015-0013-0 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Methods
Li, Yiran
Xu, Shimeng
Zhang, Xuelin
Yi, Zongchun
Cichello, Simon
Skeletal intramyocellular lipid metabolism and insulin resistance
title Skeletal intramyocellular lipid metabolism and insulin resistance
title_full Skeletal intramyocellular lipid metabolism and insulin resistance
title_fullStr Skeletal intramyocellular lipid metabolism and insulin resistance
title_full_unstemmed Skeletal intramyocellular lipid metabolism and insulin resistance
title_short Skeletal intramyocellular lipid metabolism and insulin resistance
title_sort skeletal intramyocellular lipid metabolism and insulin resistance
topic Methods
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762133/
https://www.ncbi.nlm.nih.gov/pubmed/26942223
http://dx.doi.org/10.1007/s41048-015-0013-0
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AT xushimeng skeletalintramyocellularlipidmetabolismandinsulinresistance
AT zhangxuelin skeletalintramyocellularlipidmetabolismandinsulinresistance
AT yizongchun skeletalintramyocellularlipidmetabolismandinsulinresistance
AT cichellosimon skeletalintramyocellularlipidmetabolismandinsulinresistance

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