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Cross-sectional association between serum concentrations of n-3 long-chain PUFA and depressive symptoms: results in Japanese community dwellers
The effect of n-3 long-chain PUFA (n-3 LCPUFA) on depression in healthy subjects is unclear, and most of the previous studies have focused on populations eating Western diets with lower fish intake. The present study investigated the association between blood levels of n-3 LCPUFA and depressive symp...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762234/ https://www.ncbi.nlm.nih.gov/pubmed/26689657 http://dx.doi.org/10.1017/S0007114515004754 |
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author | Horikawa, Chika Otsuka, Rei Kato, Yuki Nishita, Yukiko Tange, Chikako Kakutani, Saki Rogi, Tomohiro Kawashima, Hiroshi Shibata, Hiroshi Ando, Fujiko Shimokata, Hiroshi |
author_facet | Horikawa, Chika Otsuka, Rei Kato, Yuki Nishita, Yukiko Tange, Chikako Kakutani, Saki Rogi, Tomohiro Kawashima, Hiroshi Shibata, Hiroshi Ando, Fujiko Shimokata, Hiroshi |
author_sort | Horikawa, Chika |
collection | PubMed |
description | The effect of n-3 long-chain PUFA (n-3 LCPUFA) on depression in healthy subjects is unclear, and most of the previous studies have focused on populations eating Western diets with lower fish intake. The present study investigated the association between blood levels of n-3 LCPUFA and depressive symptoms in Japanese community dwellers with higher n-3 LCPUFA blood levels. A cross-sectional study was conducted from 2006 to 2008, including 1050 men and 1073 women aged 40 years or older from the National Institute for Longevity Sciences – the Longitudinal Study of Aging. The Center for Epidemiologic Studies Depression Scale (CES-D) was used to assess depressive symptoms. Multiple logistic regression analysis was performed to estimate the OR and 95 % CI for a CES-D score ≥16. Serum concentrations of n-3 PUFA, but not n-6 PUFA, were inversely associated with depressive symptoms. Compared with the lowest quintile, the adjusted OR for serum EPA at the fourth and fifth quintiles were 0·55 (95 % CI 0·35, 0·85) and 0·64 (95 % CI 0·42, 0·98), respectively, and at the fifth quintile for DHA it was 0·58 (95 % CI 0·37, 0·92), for the presence of depressive symptoms (P (for trend)=0·013 and 0·011, respectively). Serum levels of EPA and DHA were inversely associated with depressive symptoms in Japanese community dwellers with higher blood levels of n-3 LCPUFA, suggesting that n-3 LCPUFA intakes corresponding to higher levels in a Japanese population may have implications for a lower prevalence of depression. |
format | Online Article Text |
id | pubmed-4762234 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-47622342016-03-07 Cross-sectional association between serum concentrations of n-3 long-chain PUFA and depressive symptoms: results in Japanese community dwellers Horikawa, Chika Otsuka, Rei Kato, Yuki Nishita, Yukiko Tange, Chikako Kakutani, Saki Rogi, Tomohiro Kawashima, Hiroshi Shibata, Hiroshi Ando, Fujiko Shimokata, Hiroshi Br J Nutr Full Papers The effect of n-3 long-chain PUFA (n-3 LCPUFA) on depression in healthy subjects is unclear, and most of the previous studies have focused on populations eating Western diets with lower fish intake. The present study investigated the association between blood levels of n-3 LCPUFA and depressive symptoms in Japanese community dwellers with higher n-3 LCPUFA blood levels. A cross-sectional study was conducted from 2006 to 2008, including 1050 men and 1073 women aged 40 years or older from the National Institute for Longevity Sciences – the Longitudinal Study of Aging. The Center for Epidemiologic Studies Depression Scale (CES-D) was used to assess depressive symptoms. Multiple logistic regression analysis was performed to estimate the OR and 95 % CI for a CES-D score ≥16. Serum concentrations of n-3 PUFA, but not n-6 PUFA, were inversely associated with depressive symptoms. Compared with the lowest quintile, the adjusted OR for serum EPA at the fourth and fifth quintiles were 0·55 (95 % CI 0·35, 0·85) and 0·64 (95 % CI 0·42, 0·98), respectively, and at the fifth quintile for DHA it was 0·58 (95 % CI 0·37, 0·92), for the presence of depressive symptoms (P (for trend)=0·013 and 0·011, respectively). Serum levels of EPA and DHA were inversely associated with depressive symptoms in Japanese community dwellers with higher blood levels of n-3 LCPUFA, suggesting that n-3 LCPUFA intakes corresponding to higher levels in a Japanese population may have implications for a lower prevalence of depression. Cambridge University Press 2015-12-22 2016-02-28 /pmc/articles/PMC4762234/ /pubmed/26689657 http://dx.doi.org/10.1017/S0007114515004754 Text en © The Authors 2015 http://creativecommons.org/licenses/by/4.0/ This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Full Papers Horikawa, Chika Otsuka, Rei Kato, Yuki Nishita, Yukiko Tange, Chikako Kakutani, Saki Rogi, Tomohiro Kawashima, Hiroshi Shibata, Hiroshi Ando, Fujiko Shimokata, Hiroshi Cross-sectional association between serum concentrations of n-3 long-chain PUFA and depressive symptoms: results in Japanese community dwellers |
title | Cross-sectional association between serum concentrations of n-3 long-chain PUFA and depressive symptoms: results in Japanese community dwellers |
title_full | Cross-sectional association between serum concentrations of n-3 long-chain PUFA and depressive symptoms: results in Japanese community dwellers |
title_fullStr | Cross-sectional association between serum concentrations of n-3 long-chain PUFA and depressive symptoms: results in Japanese community dwellers |
title_full_unstemmed | Cross-sectional association between serum concentrations of n-3 long-chain PUFA and depressive symptoms: results in Japanese community dwellers |
title_short | Cross-sectional association between serum concentrations of n-3 long-chain PUFA and depressive symptoms: results in Japanese community dwellers |
title_sort | cross-sectional association between serum concentrations of n-3 long-chain pufa and depressive symptoms: results in japanese community dwellers |
topic | Full Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762234/ https://www.ncbi.nlm.nih.gov/pubmed/26689657 http://dx.doi.org/10.1017/S0007114515004754 |
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