Bipartite recognition of target RNAs activates DNA cleavage by the Type III-B CRISPR–Cas system

CRISPR–Cas systems eliminate nucleic acid invaders in bacteria and archaea. The effector complex of the Type III-B Cmr system cleaves invader RNAs recognized by the CRISPR RNA (crRNA ) of the complex. Here we show that invader RNAs also activate the Cmr complex to cleave DNA. As has been observed fo...

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Detalles Bibliográficos
Autores principales: Elmore, Joshua R., Sheppard, Nolan F., Ramia, Nancy, Deighan, Trace, Li, Hong, Terns, Rebecca M., Terns, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762429/
https://www.ncbi.nlm.nih.gov/pubmed/26848045
http://dx.doi.org/10.1101/gad.272153.115

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