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Tet2 Catalyzes Stepwise 5-Methylcytosine Oxidation by an Iterative and de novo Mechanism

[Image: see text] Modification of cytosine-guanine dinucleotides (CpGs) is a key part of mammalian epigenetic regulation and helps shape cellular identity. Tet enzymes catalyze stepwise oxidation of 5-methylcytosine (mC) in CpGs to 5-hydroxymethylcytosine (hmC), or onward to 5-formylcytosine (fC) or...

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Detalles Bibliográficos
Autores principales:	Crawford, Daniel J., Liu, Monica Yun, Nabel, Christopher S., Cao, Xing-Jun, Garcia, Benjamin A., Kohli, Rahul M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2016
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762542/ https://www.ncbi.nlm.nih.gov/pubmed/26734843 http://dx.doi.org/10.1021/jacs.5b10554

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