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Catalytic asymmetric direct aldol reaction of α-alkyl azlactones and aliphatic aldehydes
An unprecedented highly diastereoselective and enantioselective aldol reaction of α-alkyl azlactones and aliphatic aldehydes was achieved with cinchona alkaloid catalysts. To our knowledge, this reaction provides the first useful catalytic asymmetric access toward β-hydroxy-α-amino acids bearing alk...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Royal Society of Chemistry
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762611/ https://www.ncbi.nlm.nih.gov/pubmed/26918108 http://dx.doi.org/10.1039/c5sc02116b |
| _version_ | 1782417135455174656 |
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| author | Zheng, Yang Deng, Li |
| author_facet | Zheng, Yang Deng, Li |
| author_sort | Zheng, Yang |
| collection | PubMed |
| description | An unprecedented highly diastereoselective and enantioselective aldol reaction of α-alkyl azlactones and aliphatic aldehydes was achieved with cinchona alkaloid catalysts. To our knowledge, this reaction provides the first useful catalytic asymmetric access toward β-hydroxy-α-amino acids bearing alkyl substituents, which are structural motifs embedded in many natural products. |
| format | Online Article Text |
| id | pubmed-4762611 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | Royal Society of Chemistry |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-47626112016-11-01 Catalytic asymmetric direct aldol reaction of α-alkyl azlactones and aliphatic aldehydes Zheng, Yang Deng, Li Chem Sci Chemistry An unprecedented highly diastereoselective and enantioselective aldol reaction of α-alkyl azlactones and aliphatic aldehydes was achieved with cinchona alkaloid catalysts. To our knowledge, this reaction provides the first useful catalytic asymmetric access toward β-hydroxy-α-amino acids bearing alkyl substituents, which are structural motifs embedded in many natural products. Royal Society of Chemistry 2015-11-01 2015-08-04 /pmc/articles/PMC4762611/ /pubmed/26918108 http://dx.doi.org/10.1039/c5sc02116b Text en This journal is © The Royal Society of Chemistry 2015 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0) |
| spellingShingle | Chemistry Zheng, Yang Deng, Li Catalytic asymmetric direct aldol reaction of α-alkyl azlactones and aliphatic aldehydes |
| title | Catalytic asymmetric direct aldol reaction of α-alkyl azlactones and aliphatic aldehydes
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| title_full | Catalytic asymmetric direct aldol reaction of α-alkyl azlactones and aliphatic aldehydes
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| title_fullStr | Catalytic asymmetric direct aldol reaction of α-alkyl azlactones and aliphatic aldehydes
|
| title_full_unstemmed | Catalytic asymmetric direct aldol reaction of α-alkyl azlactones and aliphatic aldehydes
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| title_short | Catalytic asymmetric direct aldol reaction of α-alkyl azlactones and aliphatic aldehydes
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| title_sort | catalytic asymmetric direct aldol reaction of α-alkyl azlactones and aliphatic aldehydes |
| topic | Chemistry |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762611/ https://www.ncbi.nlm.nih.gov/pubmed/26918108 http://dx.doi.org/10.1039/c5sc02116b |
| work_keys_str_mv | AT zhengyang catalyticasymmetricdirectaldolreactionofaalkylazlactonesandaliphaticaldehydes AT dengli catalyticasymmetricdirectaldolreactionofaalkylazlactonesandaliphaticaldehydes |