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Tel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand Breaks

The cellular response to DNA double-strand breaks (DSBs) is initiated by the MRX/MRN complex (Mre11-Rad50-Xrs2 in yeast; Mre11-Rad50-Nbs1 in mammals), which recruits the checkpoint kinase Tel1/ATM to DSBs. In Saccharomyces cerevisiae, the role of Tel1 at DSBs remains enigmatic, as tel1Δ cells do not...

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Detalles Bibliográficos
Autores principales:	Cassani, Corinne, Gobbini, Elisa, Wang, Weibin, Niu, Hengyao, Clerici, Michela, Sung, Patrick, Longhese, Maria Pia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762649/ https://www.ncbi.nlm.nih.gov/pubmed/26901759 http://dx.doi.org/10.1371/journal.pbio.1002387

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