ER Adaptor SCAP Translocates and Recruits IRF3 to Perinuclear Microsome Induced by Cytosolic Microbial DNAs

Stimulator of interferon genes (STING, also known as MITA, ERIS or MPYS) induces the activation of TBK1 kinase and IRF3 transcription factor, upon sensing of microbial DNAs. How IRF3 is recruited onto the STING signalosome remains unknown. We report here that silencing of the ER adaptor SCAP markedl...

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Detalles Bibliográficos
Autores principales: Chen, Wei, Li, Senlin, Yu, Huansha, Liu, Xing, Huang, Lulu, Wang, Qiang, Liu, Heng, Cui, Ye, Tang, Yijun, Zhang, Peng, Wang, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762662/
https://www.ncbi.nlm.nih.gov/pubmed/26900919
http://dx.doi.org/10.1371/journal.ppat.1005462

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