Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques

We previously established a nanosized nasal vaccine delivery system by using a cationic cholesteryl group-bearing pullulan nanogel (cCHP nanogel), which is a universal protein-based antigen-delivery vehicle for adjuvant-free nasal vaccination. In the present study, we examined the central nervous sy...

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Detalles Bibliográficos
Autores principales: Fukuyama, Y, Yuki, Y, Katakai, Y, Harada, N, Takahashi, H, Takeda, S, Mejima, M, Joo, S, Kurokawa, S, Sawada, S, Shibata, H, Park, E J, Fujihashi, K, Briles, D E, Yasutomi, Y, Tsukada, H, Akiyoshi, K, Kiyono, H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762909/
https://www.ncbi.nlm.nih.gov/pubmed/25669148
http://dx.doi.org/10.1038/mi.2015.5

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