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Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease

Mitochondria are highly dynamic organelles that provide essential metabolic functions and represent the major bioenergetic hub of eukaryotic cell. Therefore, maintenance of mitochondria activity is necessary for the proper cellular function and survival. To this end, several mechanisms that act at d...

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Detalles Bibliográficos
Autores principales: Gumeni, Sentiljana, Trougakos, Ioannis P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763003/
https://www.ncbi.nlm.nih.gov/pubmed/26977249
http://dx.doi.org/10.1155/2016/4587691
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author Gumeni, Sentiljana
Trougakos, Ioannis P.
author_facet Gumeni, Sentiljana
Trougakos, Ioannis P.
author_sort Gumeni, Sentiljana
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description Mitochondria are highly dynamic organelles that provide essential metabolic functions and represent the major bioenergetic hub of eukaryotic cell. Therefore, maintenance of mitochondria activity is necessary for the proper cellular function and survival. To this end, several mechanisms that act at different levels and time points have been developed to ensure mitochondria quality control. An interconnected highly integrated system of mitochondrial and cytosolic chaperones and proteases along with the fission/fusion machinery represents the surveillance scaffold of mitostasis. Moreover, nonreversible mitochondrial damage targets the organelle to a specific autophagic removal, namely, mitophagy. Beyond the organelle dynamics, the constant interaction with the ubiquitin-proteasome-system (UPS) has become an emerging aspect of healthy mitochondria. Dysfunction of mitochondria and UPS increases with age and correlates with many age-related diseases including cancer and neurodegeneration. In this review, we discuss the functional cross talk of proteostasis and mitostasis in cellular homeodynamics and the impairment of mitochondrial quality control during ageing, cancer, and neurodegeneration.
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spelling pubmed-47630032016-03-14 Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease Gumeni, Sentiljana Trougakos, Ioannis P. Oxid Med Cell Longev Review Article Mitochondria are highly dynamic organelles that provide essential metabolic functions and represent the major bioenergetic hub of eukaryotic cell. Therefore, maintenance of mitochondria activity is necessary for the proper cellular function and survival. To this end, several mechanisms that act at different levels and time points have been developed to ensure mitochondria quality control. An interconnected highly integrated system of mitochondrial and cytosolic chaperones and proteases along with the fission/fusion machinery represents the surveillance scaffold of mitostasis. Moreover, nonreversible mitochondrial damage targets the organelle to a specific autophagic removal, namely, mitophagy. Beyond the organelle dynamics, the constant interaction with the ubiquitin-proteasome-system (UPS) has become an emerging aspect of healthy mitochondria. Dysfunction of mitochondria and UPS increases with age and correlates with many age-related diseases including cancer and neurodegeneration. In this review, we discuss the functional cross talk of proteostasis and mitostasis in cellular homeodynamics and the impairment of mitochondrial quality control during ageing, cancer, and neurodegeneration. Hindawi Publishing Corporation 2016 2016-02-09 /pmc/articles/PMC4763003/ /pubmed/26977249 http://dx.doi.org/10.1155/2016/4587691 Text en Copyright © 2016 S. Gumeni and I. P. Trougakos. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gumeni, Sentiljana
Trougakos, Ioannis P.
Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease
title Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease
title_full Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease
title_fullStr Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease
title_full_unstemmed Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease
title_short Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease
title_sort cross talk of proteostasis and mitostasis in cellular homeodynamics, ageing, and disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763003/
https://www.ncbi.nlm.nih.gov/pubmed/26977249
http://dx.doi.org/10.1155/2016/4587691
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