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Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease
Mitochondria are highly dynamic organelles that provide essential metabolic functions and represent the major bioenergetic hub of eukaryotic cell. Therefore, maintenance of mitochondria activity is necessary for the proper cellular function and survival. To this end, several mechanisms that act at d...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763003/ https://www.ncbi.nlm.nih.gov/pubmed/26977249 http://dx.doi.org/10.1155/2016/4587691 |
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author | Gumeni, Sentiljana Trougakos, Ioannis P. |
author_facet | Gumeni, Sentiljana Trougakos, Ioannis P. |
author_sort | Gumeni, Sentiljana |
collection | PubMed |
description | Mitochondria are highly dynamic organelles that provide essential metabolic functions and represent the major bioenergetic hub of eukaryotic cell. Therefore, maintenance of mitochondria activity is necessary for the proper cellular function and survival. To this end, several mechanisms that act at different levels and time points have been developed to ensure mitochondria quality control. An interconnected highly integrated system of mitochondrial and cytosolic chaperones and proteases along with the fission/fusion machinery represents the surveillance scaffold of mitostasis. Moreover, nonreversible mitochondrial damage targets the organelle to a specific autophagic removal, namely, mitophagy. Beyond the organelle dynamics, the constant interaction with the ubiquitin-proteasome-system (UPS) has become an emerging aspect of healthy mitochondria. Dysfunction of mitochondria and UPS increases with age and correlates with many age-related diseases including cancer and neurodegeneration. In this review, we discuss the functional cross talk of proteostasis and mitostasis in cellular homeodynamics and the impairment of mitochondrial quality control during ageing, cancer, and neurodegeneration. |
format | Online Article Text |
id | pubmed-4763003 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-47630032016-03-14 Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease Gumeni, Sentiljana Trougakos, Ioannis P. Oxid Med Cell Longev Review Article Mitochondria are highly dynamic organelles that provide essential metabolic functions and represent the major bioenergetic hub of eukaryotic cell. Therefore, maintenance of mitochondria activity is necessary for the proper cellular function and survival. To this end, several mechanisms that act at different levels and time points have been developed to ensure mitochondria quality control. An interconnected highly integrated system of mitochondrial and cytosolic chaperones and proteases along with the fission/fusion machinery represents the surveillance scaffold of mitostasis. Moreover, nonreversible mitochondrial damage targets the organelle to a specific autophagic removal, namely, mitophagy. Beyond the organelle dynamics, the constant interaction with the ubiquitin-proteasome-system (UPS) has become an emerging aspect of healthy mitochondria. Dysfunction of mitochondria and UPS increases with age and correlates with many age-related diseases including cancer and neurodegeneration. In this review, we discuss the functional cross talk of proteostasis and mitostasis in cellular homeodynamics and the impairment of mitochondrial quality control during ageing, cancer, and neurodegeneration. Hindawi Publishing Corporation 2016 2016-02-09 /pmc/articles/PMC4763003/ /pubmed/26977249 http://dx.doi.org/10.1155/2016/4587691 Text en Copyright © 2016 S. Gumeni and I. P. Trougakos. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Gumeni, Sentiljana Trougakos, Ioannis P. Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease |
title | Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease |
title_full | Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease |
title_fullStr | Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease |
title_full_unstemmed | Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease |
title_short | Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease |
title_sort | cross talk of proteostasis and mitostasis in cellular homeodynamics, ageing, and disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763003/ https://www.ncbi.nlm.nih.gov/pubmed/26977249 http://dx.doi.org/10.1155/2016/4587691 |
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