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On the Complexity of Brain Disorders: A Symptom-Based Approach
Mounting evidence shows that brain disorders involve multiple and different neural dysfunctions, including regional brain damage, change to cell structure, chemical imbalance, and/or connectivity loss among different brain regions. Understanding the complexity of brain disorders can help us map thes...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763073/ https://www.ncbi.nlm.nih.gov/pubmed/26941635 http://dx.doi.org/10.3389/fncom.2016.00016 |
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author | Moustafa, Ahmed A. Phillips, Joseph Kéri, Szabolcs Misiak, Blazej Frydecka, Dorota |
author_facet | Moustafa, Ahmed A. Phillips, Joseph Kéri, Szabolcs Misiak, Blazej Frydecka, Dorota |
author_sort | Moustafa, Ahmed A. |
collection | PubMed |
description | Mounting evidence shows that brain disorders involve multiple and different neural dysfunctions, including regional brain damage, change to cell structure, chemical imbalance, and/or connectivity loss among different brain regions. Understanding the complexity of brain disorders can help us map these neural dysfunctions to different symptom clusters as well as understand subcategories of different brain disorders. Here, we discuss data on the mapping of symptom clusters to different neural dysfunctions using examples from brain disorders such as major depressive disorder (MDD), Parkinson’s disease (PD), schizophrenia, posttraumatic stress disorder (PTSD) and Alzheimer’s disease (AD). In addition, we discuss data on the similarities of symptoms in different disorders. Importantly, computational modeling work may be able to shed light on plausible links between various symptoms and neural damage in brain disorders. |
format | Online Article Text |
id | pubmed-4763073 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-47630732016-03-03 On the Complexity of Brain Disorders: A Symptom-Based Approach Moustafa, Ahmed A. Phillips, Joseph Kéri, Szabolcs Misiak, Blazej Frydecka, Dorota Front Comput Neurosci Neuroscience Mounting evidence shows that brain disorders involve multiple and different neural dysfunctions, including regional brain damage, change to cell structure, chemical imbalance, and/or connectivity loss among different brain regions. Understanding the complexity of brain disorders can help us map these neural dysfunctions to different symptom clusters as well as understand subcategories of different brain disorders. Here, we discuss data on the mapping of symptom clusters to different neural dysfunctions using examples from brain disorders such as major depressive disorder (MDD), Parkinson’s disease (PD), schizophrenia, posttraumatic stress disorder (PTSD) and Alzheimer’s disease (AD). In addition, we discuss data on the similarities of symptoms in different disorders. Importantly, computational modeling work may be able to shed light on plausible links between various symptoms and neural damage in brain disorders. Frontiers Media S.A. 2016-02-23 /pmc/articles/PMC4763073/ /pubmed/26941635 http://dx.doi.org/10.3389/fncom.2016.00016 Text en Copyright © 2016 Moustafa, Phillips, Kéri, Misiak and Frydecka. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Moustafa, Ahmed A. Phillips, Joseph Kéri, Szabolcs Misiak, Blazej Frydecka, Dorota On the Complexity of Brain Disorders: A Symptom-Based Approach |
title | On the Complexity of Brain Disorders: A Symptom-Based Approach |
title_full | On the Complexity of Brain Disorders: A Symptom-Based Approach |
title_fullStr | On the Complexity of Brain Disorders: A Symptom-Based Approach |
title_full_unstemmed | On the Complexity of Brain Disorders: A Symptom-Based Approach |
title_short | On the Complexity of Brain Disorders: A Symptom-Based Approach |
title_sort | on the complexity of brain disorders: a symptom-based approach |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763073/ https://www.ncbi.nlm.nih.gov/pubmed/26941635 http://dx.doi.org/10.3389/fncom.2016.00016 |
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