Contiguous 2,2,4-triamino-5(2H)-oxazolone obstructs DNA synthesis by DNA polymerases α, β, η, ι, κ, REV1 and Klenow Fragment exo(−), but not by DNA polymerase ζ

Guanine is the most easily oxidized of the four DNA bases, and contiguous guanines (GG) in a sequence are more readily oxidized than a single guanine in a sequence. Continued oxidation of GGs results in a contiguous oxidized guanine lesion. Two contiguous 2,5-diamino-4H-imidazol-4-ones, an oxidized...

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Detalles Bibliográficos
Autores principales: Suzuki, Masayo, Kino, Katsuhito, Kawada, Taishu, Oyoshi, Takanori, Morikawa, Masayuki, Kobayashi, Takanobu, Miyazawa, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Regular Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763079/
https://www.ncbi.nlm.nih.gov/pubmed/26491064
http://dx.doi.org/10.1093/jb/mvv103

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