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Hypoxia-Inducible Factors (HIFs) and Phosphorylation: Impact on Stability, Localization, and Transactivity

The hypoxia-inducible factor α-subunits (HIFα) are key transcription factors in the mammalian response to oxygen deficiency. The HIFα regulation in response to hypoxia occurs primarily on the level of protein stability due to posttranslational hydroxylation and proteasomal degradation. However, HIF...

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Detalles Bibliográficos
Autores principales:	Kietzmann, Thomas, Mennerich, Daniela, Dimova, Elitsa Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763087/ https://www.ncbi.nlm.nih.gov/pubmed/26942179 http://dx.doi.org/10.3389/fcell.2016.00011

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