Liver metal levels and expression of genes related to iron homeostasis in rhesus monkeys after inhalational manganese exposure

Here we present data on liver metal levels and expression of genes related to iron homeostasis in rhesus monkeys after inhalational manganese exposure. Archived liver samples from rhesus monkeys exposed to 0 (n=6), 0.06 (n=6), 0.3 (n=4) and 1.5 (n=4) mg/m(3) manganese inhalation for 65 days were obt...

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Autores principales: Pettiglio, Michael A., Herrera, Carolina, Foster, Melanie L., Dorman, David C., Bartnikas, Thomas B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763106/
https://www.ncbi.nlm.nih.gov/pubmed/26958631
http://dx.doi.org/10.1016/j.dib.2016.01.055
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author Pettiglio, Michael A.
Herrera, Carolina
Foster, Melanie L.
Dorman, David C.
Bartnikas, Thomas B.
author_facet Pettiglio, Michael A.
Herrera, Carolina
Foster, Melanie L.
Dorman, David C.
Bartnikas, Thomas B.
author_sort Pettiglio, Michael A.
collection PubMed
description Here we present data on liver metal levels and expression of genes related to iron homeostasis in rhesus monkeys after inhalational manganese exposure. Archived liver samples from rhesus monkeys exposed to 0 (n=6), 0.06 (n=6), 0.3 (n=4) and 1.5 (n=4) mg/m(3) manganese inhalation for 65 days were obtained from a published study (“Tissue manganese concentrations in young male rhesus monkeys following subchronic manganese sulfate inhalation” [1]). Samples were analyzed by spectroscopy, immunoblotting and quantitative PCR to assess metal levels and gene expression. Liver manganese and iron levels were linearly correlated although only the intermediate manganese exposure level (0.3 mg Mn/m(3)) led to a statistically significant increase in liver iron levels.
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spelling pubmed-47631062016-03-08 Liver metal levels and expression of genes related to iron homeostasis in rhesus monkeys after inhalational manganese exposure Pettiglio, Michael A. Herrera, Carolina Foster, Melanie L. Dorman, David C. Bartnikas, Thomas B. Data Brief Data Article Here we present data on liver metal levels and expression of genes related to iron homeostasis in rhesus monkeys after inhalational manganese exposure. Archived liver samples from rhesus monkeys exposed to 0 (n=6), 0.06 (n=6), 0.3 (n=4) and 1.5 (n=4) mg/m(3) manganese inhalation for 65 days were obtained from a published study (“Tissue manganese concentrations in young male rhesus monkeys following subchronic manganese sulfate inhalation” [1]). Samples were analyzed by spectroscopy, immunoblotting and quantitative PCR to assess metal levels and gene expression. Liver manganese and iron levels were linearly correlated although only the intermediate manganese exposure level (0.3 mg Mn/m(3)) led to a statistically significant increase in liver iron levels. Elsevier 2016-02-08 /pmc/articles/PMC4763106/ /pubmed/26958631 http://dx.doi.org/10.1016/j.dib.2016.01.055 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Data Article
Pettiglio, Michael A.
Herrera, Carolina
Foster, Melanie L.
Dorman, David C.
Bartnikas, Thomas B.
Liver metal levels and expression of genes related to iron homeostasis in rhesus monkeys after inhalational manganese exposure
title Liver metal levels and expression of genes related to iron homeostasis in rhesus monkeys after inhalational manganese exposure
title_full Liver metal levels and expression of genes related to iron homeostasis in rhesus monkeys after inhalational manganese exposure
title_fullStr Liver metal levels and expression of genes related to iron homeostasis in rhesus monkeys after inhalational manganese exposure
title_full_unstemmed Liver metal levels and expression of genes related to iron homeostasis in rhesus monkeys after inhalational manganese exposure
title_short Liver metal levels and expression of genes related to iron homeostasis in rhesus monkeys after inhalational manganese exposure
title_sort liver metal levels and expression of genes related to iron homeostasis in rhesus monkeys after inhalational manganese exposure
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763106/
https://www.ncbi.nlm.nih.gov/pubmed/26958631
http://dx.doi.org/10.1016/j.dib.2016.01.055
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