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Noninvasive Assessment of Early Dental Lesion Using a Dual-Contrast Photoacoustic Tomography

Dental hard tissue lesions, including caries, cracked-tooth, etc., are the most prevalent diseases of people worldwide. Dental lesions and correlative diseases greatly decrease the life quality of patients throughout their lifetime. It is still hard to noninvasively detect these dental lesions in th...

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Autores principales: Cheng, Renxiang, Shao, Jiaojiao, Gao, Xiaoxiang, Tao, Chao, Ge, Jiuyu, Liu, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763185/
https://www.ncbi.nlm.nih.gov/pubmed/26902394
http://dx.doi.org/10.1038/srep21798
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author Cheng, Renxiang
Shao, Jiaojiao
Gao, Xiaoxiang
Tao, Chao
Ge, Jiuyu
Liu, Xiaojun
author_facet Cheng, Renxiang
Shao, Jiaojiao
Gao, Xiaoxiang
Tao, Chao
Ge, Jiuyu
Liu, Xiaojun
author_sort Cheng, Renxiang
collection PubMed
description Dental hard tissue lesions, including caries, cracked-tooth, etc., are the most prevalent diseases of people worldwide. Dental lesions and correlative diseases greatly decrease the life quality of patients throughout their lifetime. It is still hard to noninvasively detect these dental lesions in their early stages. Photoacoustic imaging is an emerging hybrid technology combining the high spatial resolution of ultrasound in deep tissue with the rich optical contrasts. In this study, a dual-contrast photoacoustic tomography is applied to detect the early dental lesions. One contrast, named B-mode, is related to the optical absorption. It is good at providing the sharp image about the morphological and macro-structural features of the teeth. Another contrast, named S-mode, is associated with the micro-structural and mechanical properties of the hard tissue. It is sensitive to the change of tissue properties induced by the early dental lesions. Experiments show that the comprehensive analysis of dual-contrast information can provide reliable information of the early dental lesions. Moreover, the imaging parameter of S-mode is device-independent and it could measure tissue properties quantitatively. We expect that the proposed scheme could be beneficial for improving safety, accuracy and sensitivity of the clinical diagnosis of the dental lesion.
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spelling pubmed-47631852016-03-01 Noninvasive Assessment of Early Dental Lesion Using a Dual-Contrast Photoacoustic Tomography Cheng, Renxiang Shao, Jiaojiao Gao, Xiaoxiang Tao, Chao Ge, Jiuyu Liu, Xiaojun Sci Rep Article Dental hard tissue lesions, including caries, cracked-tooth, etc., are the most prevalent diseases of people worldwide. Dental lesions and correlative diseases greatly decrease the life quality of patients throughout their lifetime. It is still hard to noninvasively detect these dental lesions in their early stages. Photoacoustic imaging is an emerging hybrid technology combining the high spatial resolution of ultrasound in deep tissue with the rich optical contrasts. In this study, a dual-contrast photoacoustic tomography is applied to detect the early dental lesions. One contrast, named B-mode, is related to the optical absorption. It is good at providing the sharp image about the morphological and macro-structural features of the teeth. Another contrast, named S-mode, is associated with the micro-structural and mechanical properties of the hard tissue. It is sensitive to the change of tissue properties induced by the early dental lesions. Experiments show that the comprehensive analysis of dual-contrast information can provide reliable information of the early dental lesions. Moreover, the imaging parameter of S-mode is device-independent and it could measure tissue properties quantitatively. We expect that the proposed scheme could be beneficial for improving safety, accuracy and sensitivity of the clinical diagnosis of the dental lesion. Nature Publishing Group 2016-02-23 /pmc/articles/PMC4763185/ /pubmed/26902394 http://dx.doi.org/10.1038/srep21798 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Cheng, Renxiang
Shao, Jiaojiao
Gao, Xiaoxiang
Tao, Chao
Ge, Jiuyu
Liu, Xiaojun
Noninvasive Assessment of Early Dental Lesion Using a Dual-Contrast Photoacoustic Tomography
title Noninvasive Assessment of Early Dental Lesion Using a Dual-Contrast Photoacoustic Tomography
title_full Noninvasive Assessment of Early Dental Lesion Using a Dual-Contrast Photoacoustic Tomography
title_fullStr Noninvasive Assessment of Early Dental Lesion Using a Dual-Contrast Photoacoustic Tomography
title_full_unstemmed Noninvasive Assessment of Early Dental Lesion Using a Dual-Contrast Photoacoustic Tomography
title_short Noninvasive Assessment of Early Dental Lesion Using a Dual-Contrast Photoacoustic Tomography
title_sort noninvasive assessment of early dental lesion using a dual-contrast photoacoustic tomography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763185/
https://www.ncbi.nlm.nih.gov/pubmed/26902394
http://dx.doi.org/10.1038/srep21798
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