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Noninvasive Assessment of Early Dental Lesion Using a Dual-Contrast Photoacoustic Tomography
Dental hard tissue lesions, including caries, cracked-tooth, etc., are the most prevalent diseases of people worldwide. Dental lesions and correlative diseases greatly decrease the life quality of patients throughout their lifetime. It is still hard to noninvasively detect these dental lesions in th...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763185/ https://www.ncbi.nlm.nih.gov/pubmed/26902394 http://dx.doi.org/10.1038/srep21798 |
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author | Cheng, Renxiang Shao, Jiaojiao Gao, Xiaoxiang Tao, Chao Ge, Jiuyu Liu, Xiaojun |
author_facet | Cheng, Renxiang Shao, Jiaojiao Gao, Xiaoxiang Tao, Chao Ge, Jiuyu Liu, Xiaojun |
author_sort | Cheng, Renxiang |
collection | PubMed |
description | Dental hard tissue lesions, including caries, cracked-tooth, etc., are the most prevalent diseases of people worldwide. Dental lesions and correlative diseases greatly decrease the life quality of patients throughout their lifetime. It is still hard to noninvasively detect these dental lesions in their early stages. Photoacoustic imaging is an emerging hybrid technology combining the high spatial resolution of ultrasound in deep tissue with the rich optical contrasts. In this study, a dual-contrast photoacoustic tomography is applied to detect the early dental lesions. One contrast, named B-mode, is related to the optical absorption. It is good at providing the sharp image about the morphological and macro-structural features of the teeth. Another contrast, named S-mode, is associated with the micro-structural and mechanical properties of the hard tissue. It is sensitive to the change of tissue properties induced by the early dental lesions. Experiments show that the comprehensive analysis of dual-contrast information can provide reliable information of the early dental lesions. Moreover, the imaging parameter of S-mode is device-independent and it could measure tissue properties quantitatively. We expect that the proposed scheme could be beneficial for improving safety, accuracy and sensitivity of the clinical diagnosis of the dental lesion. |
format | Online Article Text |
id | pubmed-4763185 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-47631852016-03-01 Noninvasive Assessment of Early Dental Lesion Using a Dual-Contrast Photoacoustic Tomography Cheng, Renxiang Shao, Jiaojiao Gao, Xiaoxiang Tao, Chao Ge, Jiuyu Liu, Xiaojun Sci Rep Article Dental hard tissue lesions, including caries, cracked-tooth, etc., are the most prevalent diseases of people worldwide. Dental lesions and correlative diseases greatly decrease the life quality of patients throughout their lifetime. It is still hard to noninvasively detect these dental lesions in their early stages. Photoacoustic imaging is an emerging hybrid technology combining the high spatial resolution of ultrasound in deep tissue with the rich optical contrasts. In this study, a dual-contrast photoacoustic tomography is applied to detect the early dental lesions. One contrast, named B-mode, is related to the optical absorption. It is good at providing the sharp image about the morphological and macro-structural features of the teeth. Another contrast, named S-mode, is associated with the micro-structural and mechanical properties of the hard tissue. It is sensitive to the change of tissue properties induced by the early dental lesions. Experiments show that the comprehensive analysis of dual-contrast information can provide reliable information of the early dental lesions. Moreover, the imaging parameter of S-mode is device-independent and it could measure tissue properties quantitatively. We expect that the proposed scheme could be beneficial for improving safety, accuracy and sensitivity of the clinical diagnosis of the dental lesion. Nature Publishing Group 2016-02-23 /pmc/articles/PMC4763185/ /pubmed/26902394 http://dx.doi.org/10.1038/srep21798 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Cheng, Renxiang Shao, Jiaojiao Gao, Xiaoxiang Tao, Chao Ge, Jiuyu Liu, Xiaojun Noninvasive Assessment of Early Dental Lesion Using a Dual-Contrast Photoacoustic Tomography |
title | Noninvasive Assessment of Early Dental Lesion Using a Dual-Contrast Photoacoustic Tomography |
title_full | Noninvasive Assessment of Early Dental Lesion Using a Dual-Contrast Photoacoustic Tomography |
title_fullStr | Noninvasive Assessment of Early Dental Lesion Using a Dual-Contrast Photoacoustic Tomography |
title_full_unstemmed | Noninvasive Assessment of Early Dental Lesion Using a Dual-Contrast Photoacoustic Tomography |
title_short | Noninvasive Assessment of Early Dental Lesion Using a Dual-Contrast Photoacoustic Tomography |
title_sort | noninvasive assessment of early dental lesion using a dual-contrast photoacoustic tomography |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763185/ https://www.ncbi.nlm.nih.gov/pubmed/26902394 http://dx.doi.org/10.1038/srep21798 |
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