Cargando…

The miR-34a-LDHA axis regulates glucose metabolism and tumor growth in breast cancer

Lactate dehydrogenase A (LDHA) is involved in a variety of cancers. The purpose of this study was to investigate the expression, prognostic roles and function of LDHA in breast cancer. We found that LDHA was upregulated in both breast cancer cell lines and clinical specimens using quantitative real-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiao, Xiangsheng, Huang, Xiaojia, Ye, Feng, Chen, Bo, Song, Cailu, Wen, Jiahuai, Zhang, Zhijie, Zheng, Guopei, Tang, Hailin, Xie, Xiaoming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763192/ https://www.ncbi.nlm.nih.gov/pubmed/26902416 http://dx.doi.org/10.1038/srep21735

Ejemplares similares

PDL1 And LDHA act as ceRNAs in triple negative breast cancer by regulating miR-34a
por: Huang, Xiaojia, et al.
Publicado: (2017)

Diallyl Disulfide Suppresses SRC/Ras/ERK Signaling-Mediated Proliferation and Metastasis in Human Breast Cancer by Up-Regulating miR-34a
por: Xiao, Xiangsheng, et al.
Publicado: (2014)

The miR-383-LDHA axis regulates cell proliferation, invasion and glycolysis in hepatocellular cancer
por: Fang, Zhixiong, et al.
Publicado: (2017)

circNFATC3 facilitated the progression of oral squamous cell carcinoma via the miR-520h/LDHA axis
por: Xie, Hongguo, et al.
Publicado: (2023)

miR‐200c suppresses stemness and increases cellular sensitivity to trastuzumab in HER2+ breast cancer
por: Tang, Hailin, et al.
Publicado: (2019)

miR-200c inhibits breast cancer proliferation by targeting KRAS
por: Song, Cailu, et al.
Publicado: (2015)

miR-629-3p may serve as a novel biomarker and potential therapeutic target for lung metastases of triple-negative breast cancer
por: Wang, Jin, et al.
Publicado: (2017)

MiR-638 Repressed Vascular Smooth Muscle Cell Glycolysis by Targeting LDHA
por: Chen, Shiyuan, et al.
Publicado: (2019)

Curcumin Antagonizes Glucose Fluctuation-Induced Renal Injury by Inhibiting Aerobic Glycolysis via the miR-489/LDHA Pathway
por: Fu, Xiaomei, et al.
Publicado: (2021)

mir-101-3p is a key regulator of tumor metabolism in triple negative breast cancer targeting AMPK
por: Liu, Peng, et al.
Publicado: (2016)

Indole-3-Carbinol Stabilizes p53 to Induce miR-34a, Which Targets LDHA to Block Aerobic Glycolysis in Liver Cancer Cells
por: Qi, Yuehua, et al.
Publicado: (2022)

The Practicability of a Novel Prognostic Index (PI) Model and Comparison with Nottingham Prognostic Index (NPI) in Stage I–III Breast Cancer Patients Undergoing Surgical Treatment
por: Wen, Jiahuai, et al.
Publicado: (2015)

Prognostic Significance of Preoperative Circulating Monocyte Count in Patients With Breast Cancer: Based on a Large Cohort Study
por: Wen, Jiahuai, et al.
Publicado: (2015)

Development and validation of a prognostic nomogram based on the log odds of positive lymph nodes (LODDS) for breast cancer
por: Wen, Jiahuai, et al.
Publicado: (2016)

lncRNA-DANCR Promotes Taxol Resistance of Prostate Cancer Cells through Modulating the miR-33b-5p-LDHA Axis
por: Wang, Yu-yong, et al.
Publicado: (2022)

NORAD modulates miR-30c-5p-LDHA to protect lung endothelial cells damage
por: Zhou, Yuhua, et al.
Publicado: (2022)

Inhibition of LncRNA-NEAT1 alleviates intestinal epithelial cells (IECs) dysfunction in ulcerative colitis by maintaining the homeostasis of the glucose metabolism through the miR-410-3p-LDHA axis
por: Ni, Siyi, et al.
Publicado: (2022)

Melatonin Regulates Breast Cancer Progression by the lnc010561/miR-30/FKBP3 Axis
por: Liu, Peng, et al.
Publicado: (2019)

Methylation of miR-34a, miR-34b/c, miR-124-1 and miR-203 in Ph-negative myeloproliferative neoplasms
por: Chim, Chor Sang, et al.
Publicado: (2011)

Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness
por: Ma, Wei, et al.
Publicado: (2015)

The Mechanism of miR-155/miR-15b Axis Contributed to Apoptosis of CD34+ Cells by Upregulation of PD-L1 in Myelodysplastic Syndromes
por: Cao, MeiWan, et al.
Publicado: (2023)

Quantitative Proteomic Analysis of Gene Regulation by miR-34a and miR-34c
por: Ebner, Olivia A., et al.
Publicado: (2014)

Danlou tablet inhibits high-glucose-induced cardiomyocyte apoptosis via the miR-34a-SIRT1 axis
por: Chen, Rui, et al.
Publicado: (2023)

Novel circular RNA circSLIT2 facilitates the aerobic glycolysis of pancreatic ductal adenocarcinoma via miR-510-5p/c-Myc/LDHA axis
por: Guan, Hua, et al.
Publicado: (2021)

LINC01128 facilitates the progression of pancreatic cancer through up-regulation of LDHA by targeting miR-561-5p
por: Zhong, Min, et al.
Publicado: (2022)

MiR-489-3p Reduced Pancreatic Cancer Proliferation and Metastasis By Targeting PKM2 and LDHA Involving Glycolysis
por: Zhang, Dan, et al.
Publicado: (2021)

miR-34 modulates wing polyphenism in planthopper
por: Ye, Xinhai, et al.
Publicado: (2019)

Metformin mediates induction of miR‐708 to inhibit self‐renewal and chemoresistance of breast cancer stem cells through targeting CD47
por: Tan, Weige, et al.
Publicado: (2019)

AFAP1-AS1 Promotes Epithelial-Mesenchymal Transition and Tumorigenesis Through Wnt/β-Catenin Signaling Pathway in Triple-Negative Breast Cancer
por: Zhang, Kaiming, et al.
Publicado: (2018)

Corrigendum: AFAP1-AS1 Promotes Epithelial-Mesenchymal Transition and Tumorigenesis Through Wnt/β-Catenin Signaling Pathway in Triple-Negative Breast Cancer
por: Zhang, Kaiming, et al.
Publicado: (2020)

circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a
por: He, Rongfang, et al.
Publicado: (2017)

MiR-34a and miR-34b/c have distinct effects on the suppression of lung adenocarcinomas
por: Kim, Jeong Seon, et al.
Publicado: (2019)

Analysis of the miR-34 family functions in breast cancer reveals annotation error of miR-34b
por: Engkvist, M. E., et al.
Publicado: (2017)

Fbw7 Inhibits the Progression of Activated B-Cell Like Diffuse Large B-Cell Lymphoma by Targeting the Positive Feedback Loop of the LDHA/lactate/miR-223 Axis
por: Yao, Su, et al.
Publicado: (2022)

miR-22/KAT6B axis is a chemotherapeutic determiner via regulation of PI3k-Akt-NF-kB pathway in tongue squamous cell carcinoma
por: Gu, Yixue, et al.
Publicado: (2018)

miR-139-5p and miR-451a as a Diagnostic Biomarker in LUSC
por: Gao, Bo, et al.
Publicado: (2023)

miR-200b as a prognostic factor in breast cancer targets multiple members of RAB family
por: Ye, Feng, et al.
Publicado: (2014)

USP1 promotes the aerobic glycolysis and progression of T-cell acute lymphoblastic leukemia via PLK1/LDHA axis
por: Liu, Shuguang, et al.
Publicado: (2023)

In Vivo Analysis of miR-34a Regulated Glucose Metabolism Related Genes in Megalobrama amblycephala
por: Miao, Ling-Hong, et al.
Publicado: (2018)

miR-34: from bench to bedside
por: Agostini, Massimiliano, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_t2iusumm74p4j09cb2j17sdcsf