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Protective effects of fenofibrate against acute lung injury induced by intestinal ischemia/reperfusion in mice

This experiment was conducted to evaluate whether pretreatment with fenofibrate could mitigate acute lung injury (ALI) in a mice model of intestinal ischemia/reperfusion (I/R). Male C57BL/6 mice were randomly assigned into three groups (n = 6): sham, intestinal I/R + vehicle, and intestinal I/R + fe...

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Autores principales: Zhu, Qiankun, He, Guizhen, Wang, Jie, Wang, Yukang, Chen, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763198/
https://www.ncbi.nlm.nih.gov/pubmed/26902261
http://dx.doi.org/10.1038/srep22044
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author Zhu, Qiankun
He, Guizhen
Wang, Jie
Wang, Yukang
Chen, Wei
author_facet Zhu, Qiankun
He, Guizhen
Wang, Jie
Wang, Yukang
Chen, Wei
author_sort Zhu, Qiankun
collection PubMed
description This experiment was conducted to evaluate whether pretreatment with fenofibrate could mitigate acute lung injury (ALI) in a mice model of intestinal ischemia/reperfusion (I/R). Male C57BL/6 mice were randomly assigned into three groups (n = 6): sham, intestinal I/R + vehicle, and intestinal I/R + fenofibrate. Intestinal I/R was achieved by clamping the superior mesenteric artery. Fenofibrate (100 mg/kg) or equal volume of vehicle was injected intraperitoneally 60 minutes before the ischemia. At the end of experiment, measurement of pathohistological score, inflammatory mediators and other markers were performed. In addition, a 24-hour survival experiment was conducted in intestinal I/R mice treated with fenofibrate or vehicle. The chief results were as anticipated. Pathohistological evaluation indicated that fenofibrate ameliorated the local intestine damage and distant lung injury. Pretreatment with fenofibrate significantly decreased inflammatory factors in both the intestine and the lung. Consistently, renal creatine levels and hepatic ALT levels were significantly decreased in the fenofibrate group. Moreover, serum systemic inflammatory response indicators were significantly alleviated in the fenofibrate group. In addition, fenofibrate administration significantly improved the survival rate. Collectively, our data indicated that pretreatment with fenofibrate prior to ischemia attenuated intestinal I/R injury and ALI.
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spelling pubmed-47631982016-03-01 Protective effects of fenofibrate against acute lung injury induced by intestinal ischemia/reperfusion in mice Zhu, Qiankun He, Guizhen Wang, Jie Wang, Yukang Chen, Wei Sci Rep Article This experiment was conducted to evaluate whether pretreatment with fenofibrate could mitigate acute lung injury (ALI) in a mice model of intestinal ischemia/reperfusion (I/R). Male C57BL/6 mice were randomly assigned into three groups (n = 6): sham, intestinal I/R + vehicle, and intestinal I/R + fenofibrate. Intestinal I/R was achieved by clamping the superior mesenteric artery. Fenofibrate (100 mg/kg) or equal volume of vehicle was injected intraperitoneally 60 minutes before the ischemia. At the end of experiment, measurement of pathohistological score, inflammatory mediators and other markers were performed. In addition, a 24-hour survival experiment was conducted in intestinal I/R mice treated with fenofibrate or vehicle. The chief results were as anticipated. Pathohistological evaluation indicated that fenofibrate ameliorated the local intestine damage and distant lung injury. Pretreatment with fenofibrate significantly decreased inflammatory factors in both the intestine and the lung. Consistently, renal creatine levels and hepatic ALT levels were significantly decreased in the fenofibrate group. Moreover, serum systemic inflammatory response indicators were significantly alleviated in the fenofibrate group. In addition, fenofibrate administration significantly improved the survival rate. Collectively, our data indicated that pretreatment with fenofibrate prior to ischemia attenuated intestinal I/R injury and ALI. Nature Publishing Group 2016-02-23 /pmc/articles/PMC4763198/ /pubmed/26902261 http://dx.doi.org/10.1038/srep22044 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhu, Qiankun
He, Guizhen
Wang, Jie
Wang, Yukang
Chen, Wei
Protective effects of fenofibrate against acute lung injury induced by intestinal ischemia/reperfusion in mice
title Protective effects of fenofibrate against acute lung injury induced by intestinal ischemia/reperfusion in mice
title_full Protective effects of fenofibrate against acute lung injury induced by intestinal ischemia/reperfusion in mice
title_fullStr Protective effects of fenofibrate against acute lung injury induced by intestinal ischemia/reperfusion in mice
title_full_unstemmed Protective effects of fenofibrate against acute lung injury induced by intestinal ischemia/reperfusion in mice
title_short Protective effects of fenofibrate against acute lung injury induced by intestinal ischemia/reperfusion in mice
title_sort protective effects of fenofibrate against acute lung injury induced by intestinal ischemia/reperfusion in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763198/
https://www.ncbi.nlm.nih.gov/pubmed/26902261
http://dx.doi.org/10.1038/srep22044
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