BRCA1 inhibits AR–mediated proliferation of breast cancer cells through the activation of SIRT1

Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor protein that functions to maintain genomic stability through critical roles in DNA repair, cell-cycle arrest, and transcriptional control. The androgen receptor (AR) is expressed in more than 70% of breast cancers and has been implica...

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Detalles Bibliográficos
Autores principales: Zhang, Wenwen, Luo, Jiayan, Yang, Fang, Wang, Yucai, Yin, Yongmei, Strom, Anders, Gustafsson, Jan Åke, Guan, Xiaoxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763204/
https://www.ncbi.nlm.nih.gov/pubmed/26902145
http://dx.doi.org/10.1038/srep22034

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