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Susceptibility of outer hair cells to cholesterol chelator 2-hydroxypropyl-β-cyclodextrine is prestin-dependent

Niemann-Pick type C1 disease (NPC1) is a fatal genetic disorder caused by impaired intracellular cholesterol trafficking. Recent studies reported ototoxicity of 2-hydroxypropyl- β-cyclodextrin (HPβCD), a cholesterol chelator and the only promising treatment for NPC1. Because outer hair cells (OHCs)...

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Detalles Bibliográficos
Autores principales:	Takahashi, Satoe, Homma, Kazuaki, Zhou, Yingjie, Nishimura, Shinichi, Duan, Chongwen, Chen, Jessie, Ahmad, Aisha, Cheatham, Mary Ann, Zheng, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763217/ https://www.ncbi.nlm.nih.gov/pubmed/26903308 http://dx.doi.org/10.1038/srep21973

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