T cell-specific inactivation of mouse CD2 by CRISPR/Cas9

The CRISPR/Cas9 system can be used to mutate target sequences by introduction of double-strand breaks followed by imprecise repair. To test its use for conditional gene editing we generated mice transgenic for CD4 promoter-driven Cas9 combined with guide RNA targeting CD2. We found that within CD4(+...

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Detalles Bibliográficos
Autores principales: Beil-Wagner, Jane, Dössinger, Georg, Schober, Kilian, vom Berg, Johannes, Tresch, Achim, Grandl, Martina, Palle, Pushpalatha, Mair, Florian, Gerhard, Markus, Becher, Burkhard, Busch, Dirk H., Buch, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763270/
https://www.ncbi.nlm.nih.gov/pubmed/26903281
http://dx.doi.org/10.1038/srep21377

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