TRPV1 function is modulated by Cdk5-mediated phosphorylation: insights into the molecular mechanism of nociception

TRPV1 is a polymodally activated cation channel acting as key receptor in nociceptive neurons. Its function is strongly affected by kinase-mediated phosphorylation leading to hyperalgesia and allodynia. We present behavioral and molecular data indicating that TRPV1 is strongly modulated by Cdk5-medi...

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Detalles Bibliográficos
Autores principales: Jendryke, Thomas, Prochazkova, Michaela, Hall, Bradford E., Nordmann, Grégory C., Schladt, Moritz, Milenkovic, Vladimir M., Kulkarni, Ashok B., Wetzel, Christian H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763283/
https://www.ncbi.nlm.nih.gov/pubmed/26902776
http://dx.doi.org/10.1038/srep22007

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