Transient increase of interleukin-1β after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling

It remains unclear how infantile febrile seizures (FS) enhance adult seizure susceptibility. Here we showed that the transient increase of interleukin-1β (IL-1β) after prolonged FS promoted adult seizure susceptibility, which was blocked by interleukin-1 receptor antagonist (IL-1Ra) within a critica...

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Detalles Bibliográficos
Autores principales: Feng, Bo, Tang, Yangshun, Chen, Bin, Xu, Cenglin, Wang, Yi, Dai, Yunjian, Wu, Dengchang, Zhu, Junmin, Wang, Shuang, Zhou, Yudong, Shi, Liyun, Hu, Weiwei, Zhang, Xia, Chen, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763292/
https://www.ncbi.nlm.nih.gov/pubmed/26902320
http://dx.doi.org/10.1038/srep21931

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