Variation in KRAS driver substitution distributions between tumor types is determined by both mutation and natural selection

Different tumor types vary greatly in their distribution of driver substitutions. Here, we analyzed how mutation and natural selection contribute to differences in the distribution of KRAS driver substitutions between lung, colon and pancreatic adenocarcinomas. We were able to demonstrate that both...

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Detalles Bibliográficos
Autores principales: Ostrow, Sheli L., Simon, Einav, Prinz, Elad, Bick, Tova, Shentzer, Talia, Nagawkar, Sima S., Sabo, Edmond, Ben-Izhak, Ofer, Hershberg, Ruth, Hershkovitz, Dov
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763303/
https://www.ncbi.nlm.nih.gov/pubmed/26902163
http://dx.doi.org/10.1038/srep21927

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