Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model

Thalidomide is a teratogen in humans but not in rodents. It causes multiple birth defects including malformations of limbs, ears, and other organs. However, the species-specific mechanism of thalidomide teratogenicity is not completely understood. Reproduction of the human teratogenicity of thalidom...

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Detalles Bibliográficos
Autores principales: Kazuki, Yasuhiro, Akita, Masaharu, Kobayashi, Kaoru, Osaki, Mitsuhiko, Satoh, Daisuke, Ohta, Ryo, Abe, Satoshi, Takehara, Shoko, Kazuki, Kanako, Yamazaki, Hiroshi, Kamataki, Tetsuya, Oshimura, Mitsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763305/
https://www.ncbi.nlm.nih.gov/pubmed/26903378
http://dx.doi.org/10.1038/srep21419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763305/
https://www.ncbi.nlm.nih.gov/pubmed/26903378
http://dx.doi.org/10.1038/srep21419

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